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Catalog No: OPCD03454
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OPCD03454
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Datasheets/ManualsPrintable datasheet for GATA4 Recombinant Protein (OPCD03454)
Product Info
Predicted Species ReactivityRat|Rattus norvegicus
Product FormatFreeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
HostE.coli
ConjugationUnconjugated
ApplicationPositive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
Additional InformationEndotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
Residues: Arg228-Ala440
Subcellular Location: Nucleus
Isoelectric Point: 10.1
::Phenomenon Explanation: The possible reasons that the actual band size differs from the predicted are as follows:
1) Splice Variants: Alternative splicing may create different sized proteins from the same gene.
2) Relative charge: The composition of amino acids may affect the charge of the protein.
3) Post-translational modification: Phosphorylation, glycosylation, methylation, etc.
4) Post-translation cleavage: Many proteins are synthesized as pro-proteins, and then cleaved to give the active form.
5) Polymerization of the target protein: Dimerization, multimerization, etc.
Reconstitution and Storage2°C to 8°C|-80°C
Concentration150 ug/mL (prior to lyoph)
Purity> 95%
SourceE.coli
TagN-terminal His Tag
Gene SymbolGata4
Gene Full NameGATA binding protein 4
Alias SymbolsDNA-binding protein GATA-GT2;GATA-binding factor 4;transcription factor GATA-4.
NCBI Gene Id54254
Protein NameTranscription factor GATA-4
Description of TargetTranscriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development (By similarity). In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression (By similarity). Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement (By similarity). Required during testicular development (By similarity). Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression (PubMed:15329343). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (PubMed:15329343). May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, spingosine-1-phosphate lyase (By similarity).
Uniprot IDP46152
Protein Accession #NP_653331.1
Nucleotide Accession #NM_144730.1
Protein Size (# AA)Arg228~Ala440
Molecular Weight33kDa
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