GATA4 Recombinant Protein (OPCD03453)

Catalog No: OPCD03453

GATA4 Recombinant Protein (OPCD03453) using SDS-PAGE

GATA4 Recombinant Protein (OPCD03453) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug
  Isoelectric Point: 9.7
  Residues: Arg201-Ala442
  Subcellular Location: Nucleus
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: GATA4
• Gene Full Name: GATA binding protein 4
• Alias Symbols: ASD2;GATA-binding factor 4;TACHD;TOF;transcription factor GATA-4;VSD1.
• NCBI Gene Id: 2626
• Protein Name: Transcription factor GATA-4
• Description of Target: Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development and function (PubMed:24000169, PubMed:27984724). In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression (PubMed:27984724). Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity). Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement (PubMed:20081228). Required during testicular development (PubMed:21220346). May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, spingosine-1-phosphate lyase (PubMed:15734735).
• Uniprot ID: P43694
• Protein Accession #: NP_001295022.1
• Nucleotide Accession #: NM_001308093.1
• Protein Size (# AA): Arg201~Ala442
• Molecular Weight: 30kDa