Catalog No: OACA12086
Price: $389.00
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GAPDH Recombinant Antibody [2C2] (OACA12086)

Datasheets/ManualsPrintable datasheet for GAPDH Recombinant Antibody [2C2] (OACA12086)
Product Info
Predicted Species ReactivityHuman, Mouse
Product FormatLiquid
ClonalityRecombinant Monoclonal
ApplicationEnzyme-linked immunosorbent assay,
Western blot
Reconstitution and Storage -20°C or -80°C
PurificationAffinity Purified
Gene SymbolGAPDH
Gene Full Nameglyceraldehyde-3-phosphate dehydrogenase
Alias Symbolsaging-associated gene 9 protein;epididymis secretory sperm binding protein Li 162eP;G3PD;GAPD;glyceraldehyde-3-phosphate dehydrogenase;HEL-S-162eP;OCAS, p38 component;Oct1 coactivator in S phase, 38 Kd component;peptidyl-cysteine S-nitrosylase GAPDH.
NCBI Gene Id2597
Protein NameGlyceraldehyde-3-phosphate dehydrogenase
Description of TargetHas both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation.
Uniprot IDP04406
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