GAP43 Monoclonal Antibody (OABB00037)

Catalog No: OABB00037 (Formerly GWB-BBB038)

Size:100UG

Product Info

• Tested Species Reactivity: Human, Mouse, Rat
• Predicted Species Reactivity: Human|Mouse|Rat
• Product Format: Lyophilized. Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.
• Clonality: Monoclonal
• Clone: GAP-7B10
• Isotype: Mouse IgG2a
• Application: Immunohistochemistry|Western blot
• Additional Information: Notes: Other applications have not been tested.
  Optimal dilutions should be determined by end users.
  Background: GAP43 is expressed by developing and regenerating neurons, and to a lesser extent, reactive glial cells. It is used widely to specifically label injured neurons and to score neuronal regeneration. GAP43 is also a neuronal growth cone protein thought to be involved in pathfinding. GAP43 is considered to be a crucial component of an effective regenerative response in the nervous system.
  Background: GAP43 is expressed by developing and regenerating neurons, and to a lesser extent, reactive glial cells. It is used widely to specifically label injured neurons and to score neuronal regeneration. GAP43 is also a neuronal growth cone protein thought to be involved in pathfinding. GAP43 is considered to be a crucial component of an effective regenerative response in the nervous system
• Reconstitution and Storage: 2°C to 8°C|-20°C
• Immunogen: GAP-43 from neonatal rat forebrain membranes.
• Purification: Ascites
• Predicted Homology Based on Immunogen Sequence: Human; Mouse; Rat
• Concentration: 100 ug/ml
• Specificity: No cross reactivity with other proteins.
• Formulation: Lyophilized from 1.2% sodium acetate, with 2mg BSA and 0.01mgNaN3 as preservative
• Application Info: Western blot: 0.5-1 ug/ml: Human, mouse, rat
  Immunohistochemistry (Paraffin-embedded Section): 1-2 ug/ml: Human, mouse, rat: By Heat
  Immunohistochemistry (Frozen Section): 1-2 ug/ml: Human, mouse, rat
• Storage Buffer: Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.
• Reference: 1.Kosik, K. S.; Orecchio, L. D.; Bruns, G. A. P.; Benowitz, L. I.; MacDonald, G. P.; Cox, D. R.; Neve, R.
  L. : Human GAP-43: its deduced amino acid sequence and chromosomal localization in mouse and
  human. Neuron 1: 127-132, 1988.
  2.Strittmatter, S. M.; Fankhauser, C.; Huang, P. L.; Mashimo, H.; Fishman, M. C. :
  Neuronal pathfinding is abnormal in mice lacking the neuronal growth cone protein GAP-43. Cell 80:
  445-452, 1995.
• Description: Mouse IgG monoclonal antibody for GAP43, growth associated protein 43 (GAP43) detection. Tested with WB, IHC-P, IHC-F in Human;mouse; rat. No cross reactivity with otherproteins.

Target Info

• Gene Symbol: Gap43
• Gene Full Name: growth associated protein 43
• Alias Symbols: axonal membrane protein GAP-43;Basp2;brain abundant, membrane attached signal protein 2;growth accentuating protein 43;Growth-associated protein 43;neuromodulin;protein F1.
• NCBI Gene Id: 29423
• Protein Name: Neuromodulin
• Description of Target: This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction (By similarity).
• Uniprot ID: P07936
• Molecular Weight: 23603 MW