GABBR1 Antibody (OAAJ01761)

Catalog No: OAAJ01761

Size:100 ul

Western blot analysis on HeLa cell lysate using GABBR1 Antibody

Product Info

• Predicted Species Reactivity: Human, Mouse, Rat
• Product Format: Liquid. Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB, IHC
• Reconstitution and Storage: Store at -20C. Stable for 12 months from date of receipt.
• Immunogen: A synthesized peptide derived from human GABBR1
• Purification: Affinity-chromatography
• Concentration: 1 mg/ml
• Specificity: GABBR1 antibody detects endogenous levels of total GABBR1
• Application Info: WB: 1:500~1:3000 IHC: 1:50~1:200

Target Info

• Gene Symbol: GABBR1
• Gene Full Name: gamma-aminobutyric acid (GABA) B receptor, 1
• Alias Symbols: GB1, GPRC3A, GABABR1, GABBR1-3
• NCBI Gene Id: 2550
• Description of Target: GABBR1 Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high- voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. Activated by (-)-baclofen, cgp27492 and blocked by phaclofen. Heterodimer of GABA-B-R1 and GABA-B-R2. Neither of which is effective on its own and homodimeric assembly does not seem to happen. Isoform 1E (without C-terminal intracellular domain) is unable to dimerize via a coiled-coil interaction with GABA-B-R2. Interacts with the leucine zipper of the C-terminal bZIP domain of ATF4 via its C-terminal region. Interacts with JAKMIP1.
• Uniprot ID: Q9UBS5
• Molecular Weight: 110 kDa