Size:100ug
$379.00
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OASE00251
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Conjugation Options

OASE00251-FITC Conjugated

OASE00251-HRP Conjugated

OASE00251-Biotin Conjugated

GABA-B Receptor 1 Antibody (OASE00251)

Catalog#: OASE00251
Domestic: within 3-5 days delivery | International: 3-5 days
More Information
Predicted Species Reactivity Human, Mouse, Rat
Clonality Monoclonal
Clone S93A-49
Isotype IgG1
Host Mouse
Application WB, ICC
Additional Information Background Info: Detects ~115kDa. No cross-reactivity against GABA(B)R2
:: Scientific Background: GABA (?-aminobutyric acid) is the primary inhibitory neurotransmitter in the central nervous system and interacts with three different receptors: GABA(A), GABA(B) and GABA(C) receptor. The ionotropic GABA(A) and GABA(C) receptors are ligand-gated ion channels that produce fast inhibitory synaptic transmission. In contrast, the metabotropic GABA(B) receptor is coupled to G proteins that modulate slow inhibitory synaptic transmission (1). Functional GABA(B) receptors form heterodimers of GABA(B)R1 and GABA(B)R2 where GABA(B)R1 binds the ligand and GABA(B)R2 is the primary G protein contact site (2). Two isoforms of GABA(B)R1 have been cloned: GABA(B)R1a is a 130 kD protein and GABA(B)R1b is a 95 kD protein (3). G proteins subsequently inhibit adenyl cylase activity and modulate inositol phospholipid hydrolysis. GABA(B) receptors have both pre- and postsynaptic inhibitions: presynaptic GABA(B) receptors inhibit neurotransmitter release through suppression of high threshold calcium channels, while postsynaptic GABA(B) receptors inhibit through coupled activation of inwardly rectifying potassium channels. In addition to synaptic inhibition, GABA(B) receptors may also be involved in hippocampal long-term potentiation, slow wave sleep and muscle relaxation (1).
:: Certificate of Analysis: 1ug/mL was sufficient for detection of GABA(B)R1 in 20ug of rat brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
Reconstitution and Storage Store at -20C. Shipping in Blue Ice or 4C.
Replacement Item This antibody may replace item sc-116203 from Santa Cruz Biotechnology.
Immunogen Fusion protein amino acids 873-977 (cytoplasmic C-terminus) of rat GABA(B)R1
Purification Protein G Purified
Concentration 1mg/mL
Datasheets/Manuals Printable datasheet for OASE00251
Dilution 1:1000 (WB)
Storage Buffer PBS pH7.4, 50% glycerol
Target Reference 1. Jones K.A. et al. (2000) Neuropsychopharmacology 23: 2. Duthey B. et al. (2002) J Biol Chem. 277: 3236-41.
3. Kaupmann K. et al. (1997) Nature 386: 239-46.
Gene Symbol Gabbr1
Official Gene Full Name gamma-aminobutyric acid (GABA) B receptor 1
NCBI Gene Id 81657
Swissprot Id Q9Z0U4
Protein Accession # NP_112290.2
Tissue Tool Find tissues and cell lines supported by DNA array analysis to express Gabbr1.
RNA Seq Find tissues and cell lines supported by RNA-seq analysis to express Gabbr1.
  1. What is the species homology for "GABA-B Receptor 1 Antibody (OASE00251)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human, Mouse, Rat".

  2. How long will it take to receive "GABA-B Receptor 1 Antibody (OASE00251)"?

    This item is available "Domestic: within 3-5 days delivery | International: 3-5 days".

  3. What buffer format is "GABA-B Receptor 1 Antibody (OASE00251)" provided in?

    This item is provided in "".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "GABA-B Receptor 1 Antibody (OASE00251)"?

    This target may also be called "" in publications.

  5. What is the shipping cost for "GABA-B Receptor 1 Antibody (OASE00251)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "GABA-B Receptor 1 Antibody (OASE00251)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "GABA-B Receptor 1 Antibody (OASE00251)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "GABA-B Receptor 1 Antibody (OASE00251)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data tab on the product page.

  10. What are positive controls for "GABBR1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "GABBR1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "GABBR1"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "GABBR1"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "GABBR1"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "GABBR1"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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