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G6PC Antibody - N-terminal region (ARP44224_P050)

100 ul
$319.00
In Stock
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Conjugation Options

ARP44224_P050-FITC Conjugated

ARP44224_P050-HRP Conjugated

ARP44224_P050-Biotin Conjugated

Gene Symbol:
G6PC
Official Gene Full Name:
Glucose-6-phosphatase, catalytic subunit
NCBI Gene Id:
2538
Protein Name:
Glucose-6-phosphatase
Swissprot Id:
P35575
Protein Accession #:
NP_000142
Nucleotide Accession #:
NM_000151
Alias Symbols:
G6PT, GSD1a, MGC163350, GSD1, G6PC1
Replacement Item:
This antibody may replace item sc-105380 from Santa Cruz Biotechnology.
Description of Target:
G6PC hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum.It forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels.Glucose-6-phosphatase is an integral membrane protein of the endoplasmic reticulum that catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate. It is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Defects in the enzyme cause glycogen storage disease type I (von Gierke disease). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Protein Size (# AA):
357
Molecular Weight:
40kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Affinity Purified
Application:
IHC, WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express G6PC.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express G6PC.
Immunogen:
The immunogen is a synthetic peptide directed towards the N terminal region of human G6PC
Predicted Species Reactivity:
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Sheep
Tested Species Reactivity:
Human
Predicted Homology Based on Immunogen Sequence:
Cow: 93%; Dog: 100%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 86%; Pig: 100%; Rabbit: 93%; Rat: 93%; Sheep: 100%
Complete computational species homology data:
Anti-G6PC (ARP44224_P050)
Peptide Sequence:
Synthetic peptide located within the following region: NLVFKWILFGQRPYWWVLDTDYYSNTSVPLIKQFPVTCETGPGSPSGHAM
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
NSL1; SNX13; CDH16; FOXO1;
Blocking Peptide:
For anti-G6PC (ARP44224_P050) antibody is Catalog # AAP44224 (Previous Catalog # AAPP25604)
Datasheets/Manuals:
Printable datasheet for anti-G6PC (ARP44224_P050) antibody
Additional Information:
IHC Information: Kidney, Human: Formalin-Fixed, Paraffin-Embedded (FFPE)
Target Reference:
Barkaoui,E., J. Inherit. Metab. Dis. 30 (6), 989 (2007)
Publications:

Iwasa, M. et al. Branched-chain amino acid supplementation reduces oxidative stress and prolongs survival in rats with advanced liver cirrhosis. PLoS One 8, e70309 (2013). IHC, WB, Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Sheep 23936183

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