Size:100 ul
$289.00
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SKU
ARP51279_P050
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Conjugation Options

ARP51279_P050-FITC Conjugated

ARP51279_P050-HRP Conjugated

ARP51279_P050-Biotin Conjugated

More Information
Tested Species Reactivity Human
Predicted Species Reactivity Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rat, Zebrafish
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Clonality Polyclonal
Host Rabbit
Application WB
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Replacement Item This antibody may replace item sc-166714 from Santa Cruz Biotechnology.
Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human FZR1
Purification Affinity Purified
Predicted Homology Based on Immunogen Sequence Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rat: 100%; Zebrafish: 100%
Complete computational species homology data ARP51279_P050
Peptide Sequence Synthetic peptide located within the following region: SSPVSSPSKHGDRFIPSRAGANWSVNFHRINENEKSPSQNRKAKDATSDN
Concentration Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Blocking Peptide Catalog # AAP51279 (Previous Catalog # AAPS22306)
Datasheets/Manuals Printable datasheet for ARP51279_P050
Sample Type Confirmation

FZR1 is strongly supported by BioGPS gene expression data to be expressed in 721_B

Publications

Hu, R; Li, L; Li, D; Tan, W; Wan, L; Zhu, C; Zhang, Y; Zhang, C; Yao, W; Downregulation of Cdh1 signalling in spinal dorsal horn contributes to the maintenance of mechanical allodynia after nerve injury in rats. 12, (2016). WB, Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rat, Zebrafish 27184142

Gene Symbol FZR1
Official Gene Full Name Fizzy/cell division cycle 20 related 1 (Drosophila)
Alias Symbols CDC20C, CDH1, FZR, FZR2, HCDH, HCDH1, KIAA1242
NCBI Gene Id 51343
Protein Name Fizzy-related protein homolog
Description of Target FZR1 is a key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. FZR1 associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.
Swissprot Id Q9UM11
Protein Accession # NP_057347
Nucleotide Accession # NM_016263
Protein Size (# AA) 493
Molecular Weight 55kDa
Tissue Tool Find tissues and cell lines supported by DNA array analysis
RNA Seq Find tissues and cell lines supported by RNA-seq analysis
Protein Interactions ZC3HC1; CDC25A; CCNB1; UBE2S; UBE2C; PTTG1; UBE2D2; TP53; CDR2; UBE2K; ANAPC4; PDS1; STAU1; CDK2; CDC27; RACGAP1; FOXM1; HECW2; PHF8; BTRC; CCNA1; UBC; SOX2; SKP2; PLK1; CUL1; CUEDC2; CDC20; kif22; SIRT2; CLSPN; ANAPC11; CDC14B; VHL; PTEN; EYA1; DAXX; BUB
  1. What is the species homology for "FZR1 Antibody - N-terminal region (ARP51279_P050)"?

    The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rat, Zebrafish".

  2. How long will it take to receive "FZR1 Antibody - N-terminal region (ARP51279_P050)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "FZR1 Antibody - N-terminal region (ARP51279_P050)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "FZR1 Antibody - N-terminal region (ARP51279_P050)"?

    This target may also be called "CDC20C, CDH1, FZR, FZR2, HCDH, HCDH1, KIAA1242" in publications.

  5. What is the shipping cost for "FZR1 Antibody - N-terminal region (ARP51279_P050)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "FZR1 Antibody - N-terminal region (ARP51279_P050)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "FZR1 Antibody - N-terminal region (ARP51279_P050)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "55kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "FZR1 Antibody - N-terminal region (ARP51279_P050)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data tab on the product page.

  10. What are positive controls for "FZR1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "FZR1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "FZR1"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "FZR1"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "FZR1"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "FZR1"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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