FZD7 Antibody (OABF01524)

Catalog No: OABF01524

Size:100UL

Product Info

• Predicted Species Reactivity: Bovine|Chicken|Dog|Guinea Pig|Human|Mouse|Porcine|Rat
• Product Format: Liquid Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Flow cytometry|Immunocytochemistry|Immunofluorescence|Immunohistochemistry-Frozen|Immunohistochemistry-Paraffin|Western blot
• Additional Information: Subcellular location: Cytoplasm
• Reconstitution and Storage: -20°C
• Immunogen: KLH conjugated synthetic peptide derived from human Frizzled 7
• Purification: Protein A Purified
• Concentration: 1 ug/ul
• Application Info: WB: 1:100~1000
  IHC-P: 1:100~500
  Fluorescent-IHC: 1:50~200

Target Info

• Gene Symbol: FZD7
• Gene Full Name: frizzled class receptor 7
• Alias Symbols: frizzled 7, seven transmembrane spanning receptor;frizzled family receptor 7;frizzled homolog 7;Frizzled, drosophila, homolog of, 7;frizzled-7;fz-7;FzE3;hFz7.
• NCBI Gene Id: 8324
• Protein Name: Frizzled-7
• Description of Target: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
• Uniprot ID: O75084