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FZD7 antibody - C-terminal region (ARP41251_P050)

100 ul
$319.00
In Stock

Conjugation Options

ARP41251_P050-FITC Conjugated

ARP41251_P050-HRP Conjugated

ARP41251_P050-Biotin Conjugated

Gene Symbol:
FZD7
NCBI Gene Id:
8324
Official Gene Full Name:
Frizzled family receptor 7
Protein Name:
Frizzled-7
Swissprot Id:
O75084
Protein Accession #:
NP_003498
Nucleotide Accession #:
NM_003507
Alias Symbols:
FzE3
Replacement Item:
This antibody may replace item sc-293261 from Santa Cruz Biotechnology.
Description of Target:
FZD7 is 7-transmembrane domain protein that is receptor for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif.Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.
Protein Size (# AA):
574
Molecular Weight:
63kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Affinity Purified
Application:
IHC, WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express FZD7.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express FZD7.
Immunogen:
The immunogen is a synthetic peptide directed towards the C terminal region of human FZD7
Species Reactivity:
Cow, Dog, Guinea Pig, Human, Mouse, Pig, Rabbit, Rat, Yeast
Predicted Homology Based on Immunogen Sequence:
Cow: 100%; Dog: 100%; Guinea Pig: 93%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Yeast: 82%
Complete computational species homology data:
Anti-FZD7 (ARP41251_P050)
Peptide Sequence:
Synthetic peptide located within the following region: PDFTVFMIKYLMTMIVGITTGFWIWSGKTLQSWRRFYHRLSHSSKGETAV
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
UBC; UBQLN4; MAGI3; UBQLN1; DLG2; DLG4; DLG1;
Blocking Peptide:
For anti-FZD7 (ARP41251_P050) antibody is Catalog # AAP41251 (Previous Catalog # AAPP22606)
Datasheets/Manuals:
Printable datasheet for anti-FZD7 (ARP41251_P050) antibody
Target Reference:
Vincan,E., (2005) Differentiation 73 (4), 142-153
Publications:

Ueno, K. et al. Frizzled-7 as a potential therapeutic target in colorectal cancer. Neoplasia 10, 697-705 (2008). IHC, WB, Cow, Dog, Guinea Pig, Human, Mouse, Pig, Rabbit, Rat, Yeast 18592008

Gökmen-Polar, Y. et al. Dual targeting of EphA2 and ER restores tamoxifen sensitivity in ER/EphA2-positive breast cancer. Breast Cancer Res. Treat. 127, 375-84 (2011). IHC, WB, Cow, Dog, Guinea Pig, Human, Mouse, Pig, Rabbit, Rat, Yeast 20602165

Ohba, S., Lanigan, T. M. & Roessler, B. J. Leptin receptor JAK2/STAT3 signaling modulates expression of Frizzled receptors in articular chondrocytes. Osteoarthritis Cartilage 18, 1620-9 (2010). IHC, WB, Cow, Dog, Guinea Pig, Human, Mouse, Pig, Rabbit, Rat, Yeast 20868760

Schmuck, R. et al. Genotypic and phenotypic characterization of side population of gastric cancer cell lines. Am. J. Pathol. 178, 1792-804 (2011). IHC, WB, Cow, Dog, Guinea Pig, Human, Mouse, Pig, Rabbit, Rat, Yeast 21435459

McIver, S. C. et al. A unique combination of male germ cell miRNAs coordinates gonocyte differentiation. PLoS One 7, e35553 (2012). IHC, WB, Cow, Dog, Guinea Pig, Human, Mouse, Pig, Rabbit, Rat, Yeast 22536405

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