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Catalog No: OAAF00768 (Formerly GWB-ASC182)
Size:100 ug
Price: $344.00
SKU
OAAF00768
Availability: Domestic: within 1-2 week delivery | International: 1-2 weeks
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  • $55: Antibody & Protein in US
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Datasheets/ManualsPrintable datasheet for FOXO3 Antibody (OAAF00768)
Product Info
Predicted Species ReactivityHuman|Mouse|Rat
Product FormatLiquid
ClonalityPolyclonal
HostRabbit
ApplicationEnzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry|Immunohistochemistry-Paraffin|Western blot
Reconstitution and Storage-20°C
ImmunogenThe antiserum was produced against synthesized peptide derived from human FOXO1/3/4.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
SpecificityFOXO1/3/4-pan antibody detects endogenous levels of total FOXO1/3/4-pan protein.
FormulationRabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
DilutionThe optimal working dilution should be determined by the end user.
Application InfoIHC: 1:50~1:100; ELISA: 1:1000
ReferenceRobert J. Southgate, J. Biol. Chem., Jul 2007; 282: 21176 - 21186.
Susumu Kodama, Mol. Cell. Biol., Sep 2004; 24: 7931 - 7940.
Dragan Marinkovic, J. Clin. Invest., Aug 2007; 117: 2133 - 2144.
Marie-Liesse Asselin-Labat, Blood, Jul 2004; 104
Gene SymbolFOXO1|FOXO3|FOXO4
Gene Full Nameforkhead box O1|forkhead box O3|forkhead box O4
Alias SymbolsAF6q21;AF6q21 protein;AFX;AFX1;FKH1;FKHR;FKHRL1;FKHRL1P2;fork head domain transcription factor AFX1;forkhead box O3A;forkhead box protein O1;forkhead box protein O1A;forkhead box protein O3;forkhead box protein O4;forkhead homolog (rhabdomyosarcoma) like 1;Forkhead in rhabdomyosarcoma;forkhead in rhabdomyosarcoma-like 1;forkhead, Drosophila, homolog of, in rhabdomyosarcoma;forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1;FOXO1A;FOXO2;FOXO3A;FOXO3A-;MLLT7;myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7.
NCBI Gene Id2308|2309|4303
Protein NameForkhead box protein O1|Forkhead box protein O3|Forkhead box protein O4
Description of TargetTranscription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity.|Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity. Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP. In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC and PCK1. Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and STK4/MST1. Promotes neural cell death. Mediates insulin action on adipose tissue. Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake. Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells. Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner. Mediates the function of MLIP in cardiomyocytes hypertrophy and cardiac remodeling (By similarity).|Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (PubMed:10102273, PubMed:16751106). Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' (PubMed:21329882). Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (PubMed:21329882). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription (PubMed:23283301).
Uniprot IDO43524|P98177|Q12778
Protein Accession #NP_001164402.1
Molecular Weight69 kDa
  1. What is the species homology for "FOXO3 Antibody (OAAF00768)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human|Mouse|Rat".

  2. How long will it take to receive "FOXO3 Antibody (OAAF00768)"?

    This item is available "Domestic: within 1-2 week delivery | International: 1-2 weeks".

  3. What buffer format is "FOXO3 Antibody (OAAF00768)" provided in?

    This item is provided in "Liquid".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "FOXO3 Antibody (OAAF00768)"?

    This target may also be called "AF6q21;AF6q21 protein;AFX;AFX1;FKH1;FKHR;FKHRL1;FKHRL1P2;fork head domain transcription factor AFX1;forkhead box O3A;forkhead box protein O1;forkhead box protein O1A;forkhead box protein O3;forkhead box protein O4;forkhead homolog (rhabdomyosarcoma) like 1;Forkhead in rhabdomyosarcoma;forkhead in rhabdomyosarcoma-like 1;forkhead, Drosophila, homolog of, in rhabdomyosarcoma;forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1;FOXO1A;FOXO2;FOXO3A;FOXO3A-;MLLT7;myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7." in publications.

  5. What is the shipping cost for "FOXO3 Antibody (OAAF00768)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "FOXO3 Antibody (OAAF00768)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "FOXO3 Antibody (OAAF00768)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "69 kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "FOXO3 Antibody (OAAF00768)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "FOXO1|FOXO3|FOXO4"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "FOXO1|FOXO3|FOXO4"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "FOXO1|FOXO3|FOXO4"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "FOXO1|FOXO3|FOXO4"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "FOXO1|FOXO3|FOXO4"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "FOXO1|FOXO3|FOXO4"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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