FOXA2 Antibody - middle region : Biotin (ARP31944_P050-Biotin)

Catalog No: ARP31944_P050-Biotin

Size:100ul

Product Info

• Predicted Species Reactivity: Human, Mouse, Rat, Dog, Horse, Pig, Rabbit
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer.
• Clonality: Polyclonal
• Host: Rabbit
• Conjugation: Biotin
• Application: WB
• Reconstitution and Storage: All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human FOXA2
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Dog: 100%; Horse: 100%; Human: 100%; Mouse: 92%; Pig: 100%; Rabbit: 77%; Rat: 92%
• Peptide Sequence: Synthetic peptide located within the following region: ASQAQLGEAAGPASETPAGTESPHSSASPCQEHKRGGLGELKGTPAAALS
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-FOXA2 (ARP31944_P050-Biotin) antibody is Catalog # AAP31944 (Previous Catalog # AAPP02841)
• Sample Type Confirmation:

  FOXA2 is strongly supported by BioGPS gene expression data to be expressed in 721_B, HepG2

• Reference: Yang,G., (2008) Blood 111 (1), 392-401
• Publications:

  Richards, T. J. et al. Allele-specific transactivation of matrix metalloproteinase 7 by FOXA2 and correlation with plasma levels in idiopathic pulmonary fibrosis. Am. J. Physiol. Lung Cell. Mol. Physiol. 302, L746-54 (2012). WB, Human, Dog, Pig, Horse, Mouse, Rat, Rabbit 22268124

  Menga, A. et al. Insight into mechanism of in vitro insulin secretion increase induced by antipsychotic clozapine: role of FOXA1 and mitochondrial citrate carrier. Eur. Neuropsychopharmacol. 23, 978-87 (2013). WB, Human, Dog, Pig, Horse, Mouse, Rat, Rabbit 22959654

  Kallas, A., Pook, M., Trei, A. & Maimets, T. SOX2 Is Regulated Differently from NANOG and OCT4 in Human Embryonic Stem Cells during Early Differentiation Initiated with Sodium Butyrate. Stem Cells Int. 2014, 298163 (2014). WB, Human, Dog, Pig, Horse, Mouse, Rat, Rabbit 24707296

Target Info

• Gene Symbol: FOXA2
• Gene Full Name: Forkhead box A2
• Alias Symbols: HNF3B, TCF3B, HNF-3-beta
• NCBI Gene Id: 3170
• Protein Name: Hepatocyte nuclear factor 3-beta
• Description of Target: FOXA2 is a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young.This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young. Two transcript variants encoding the same protein have been identified for this gene. This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young. Two transcript variants encoding the same protein have been identified for this gene.
• Uniprot ID: Q9Y261
• Protein Accession #: NP_068556
• Nucleotide Accession #: NM_021784
• Protein Size (# AA): 457
• Molecular Weight: 48kDa
• Protein Interactions: PPARGC1B; GSC; EN2; OTX2; ONECUT1; NCOA1; TLE1; MIP; HOXA5; LHX1;