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FOXA2 Antibody - C-terminal region (OAAB18917)

400 ul
$329.00
In Stock
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Predicted Species Reactivity:
Human
Product Format:
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Host:
Rabbit
Application:
WB
Reconstitution and Storage:
Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Gene Symbol:
FOXA2
NCBI Gene Id:
3170
Swissprot Id:
Q9Y261; P32182; P35583
Alias Symbols:
Hepatocyte nuclear factor 3-beta, HNF-3-beta, HNF-3B, Forkhead box protein A2, Transcription factor 3B, TCF-3B, FOXA2, HNF3B, TCF3B
Replacement Item:
This antibody may replace item sc-101060 from Santa Cruz Biotechnology.
Description of Target:
Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.
Molecular Weight:
48 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express FOXA2.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express FOXA2.
Immunogen:
This FOXA2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 355-389 amino acids from the C-terminal region of human FOXA2.
Predicted Homology Based on Immunogen Sequence:
Mouse, Rat
Datasheets/Manuals:
Printable datasheet for anti-FOXA2 (OAAB18917) antibody
Application Info:
WB: 1:1000
Target Reference:
Yamada S.,et al.Diabetologia 43:121-124(2000).
Hinokio Y.,et al.Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
Navas M.A.,et al.Hum. Hered. 50:370-381(2000).
Deloukas P.,et al.Nature 414:865-871(2001).
Wolfrum C.,et al.Proc. Natl. Acad. Sci. U.S.A. 100:11624-11629(2003).

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