Size:400 ul
$329.00
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SKU
OAAB18917
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FOXA2 Antibody - C-terminal region (OAAB18917)

Catalog#: OAAB18917
Domestic: within 1 week delivery | International: 1 week
More Information
Predicted Species Reactivity Human
Product Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Clonality Polyclonal
Isotype Rabbit Ig
Host Rabbit
Application WB
Reconstitution and Storage Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Replacement Item This antibody may replace item sc-101060 from Santa Cruz Biotechnology.
Immunogen This FOXA2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 355-389 amino acids from the C-terminal region of human FOXA2.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Predicted Homology Based on Immunogen Sequence Mouse, Rat
Datasheets/Manuals Printable datasheet for anti-FOXA2 (OAAB18917) antibody
Application Info WB: 1:1000
Target Reference Yamada S.,et al.Diabetologia 43:121-124(2000).
Hinokio Y.,et al.Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
Navas M.A.,et al.Hum. Hered. 50:370-381(2000).
Deloukas P.,et al.Nature 414:865-871(2001).
Wolfrum C.,et al.Proc. Natl. Acad. Sci. U.S.A. 100:11624-11629(2003).
Gene Symbol FOXA2
Alias Symbols Hepatocyte nuclear factor 3-beta, HNF-3-beta, HNF-3B, Forkhead box protein A2, Transcription factor 3B, TCF-3B, FOXA2, HNF3B, TCF3B
NCBI Gene Id 3170
Description of Target Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.
Swissprot Id Q9Y261; P32182; P35583
Molecular Weight 48 kDa
Tissue Tool Find tissues and cell lines supported by DNA array analysis to express FOXA2.
RNA Seq Find tissues and cell lines supported by RNA-seq analysis to express FOXA2.
  1. What is the species homology for "FOXA2 Antibody - C-terminal region (OAAB18917)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".

  2. How long will it take to receive "FOXA2 Antibody - C-terminal region (OAAB18917)"?

    This item is available "Domestic: within 1 week delivery | International: 1 week".

  3. What buffer format is "FOXA2 Antibody - C-terminal region (OAAB18917)" provided in?

    This item is provided in "Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "FOXA2 Antibody - C-terminal region (OAAB18917)"?

    This target may also be called "Hepatocyte nuclear factor 3-beta, HNF-3-beta, HNF-3B, Forkhead box protein A2, Transcription factor 3B, TCF-3B, FOXA2, HNF3B, TCF3B" in publications.

  5. What is the shipping cost for "FOXA2 Antibody - C-terminal region (OAAB18917)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "FOXA2 Antibody - C-terminal region (OAAB18917)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "FOXA2 Antibody - C-terminal region (OAAB18917)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "48 kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "FOXA2 Antibody - C-terminal region (OAAB18917)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data tab on the product page.

  10. What are positive controls for "FOXA2"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "FOXA2"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "FOXA2"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "FOXA2"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "FOXA2"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "FOXA2"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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