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Datasheets/Manuals | Printable datasheet for anti-Foxa2 (ARP37059_P050) antibody |
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Tested Species Reactivity | Mouse |
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Predicted Species Reactivity | Mouse, Rat |
Product Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Clonality | Polyclonal |
Host | Rabbit |
Application | WB |
Reconstitution and Storage | For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Immunogen | The immunogen is a synthetic peptide corresponding to a region of Mouse |
Purification | Affinity Purified |
Predicted Homology Based on Immunogen Sequence | Mouse: 100%; Rat: 86% |
Peptide Sequence | Synthetic peptide located within the following region: VDVEGTDYLNGDLGWSSSVSDSDERGSMQSLGSDEGYSSATVKRAKLQDG |
Concentration | 0.5 mg/ml |
Blocking Peptide | For anti-Foxa2 (ARP37059_P050) antibody is Catalog # AAP37059 (Previous Catalog # AAPS06804) |
Gene Symbol | Foxa2 |
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Gene Full Name | Forkhead box A2 |
Alias Symbols | Hnf3, Hnf-3, Hnf3b, Tcf3b, HNF3be, Hnf-3b, Tcf-3b, HNF3-be, HNF3beta, HNF3-beta |
NCBI Gene Id | 15376 |
Protein Name | Hepatocyte nuclear factor 3-beta |
Description of Target | Foxa2 is a transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Foxa2 is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. In embryonic development Foxa2 is required for notochord formation. Foxa2 is involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; Foxa1 and Foxa2 seem to have at least in part redundant roles. Foxa2 modulates the transcriptional activity of nuclear hormone receptors; inhibits AR-mediated transcription from the LCN5 promoter. Foxa2 binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation. Foxa2 interacts with the cis-acting regulatory regions of these genes. Foxa2 is involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Foxa2 is involved in regulation of fat metabolism; activates transcriptional programs of lipid metabolism and ketogenesis at low insulin state. |
Uniprot ID | P35583 |
Protein Accession # | NP_034576 |
Nucleotide Accession # | NM_010446 |
Protein Size (# AA) | 459 |
Molecular Weight | 48kDa |
Protein Interactions | Ucp2; Gck; Pklr; Hnf4a; Igfbp1; Acadm; Acadvl; |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "Foxa2 Antibody - C-terminal region (ARP37059_P050)"?
The tested species reactivity for this item is "Mouse". This antibody is predicted to have homology to "Mouse, Rat".
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How long will it take to receive "Foxa2 Antibody - C-terminal region (ARP37059_P050)"?
This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".
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What buffer format is "Foxa2 Antibody - C-terminal region (ARP37059_P050)" provided in?
This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "Foxa2 Antibody - C-terminal region (ARP37059_P050)"?
This target may also be called "Hnf3, Hnf-3, Hnf3b, Tcf3b, HNF3be, Hnf-3b, Tcf-3b, HNF3-be, HNF3beta, HNF3-beta" in publications.
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What is the shipping cost for "Foxa2 Antibody - C-terminal region (ARP37059_P050)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "Foxa2 Antibody - C-terminal region (ARP37059_P050)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "Foxa2 Antibody - C-terminal region (ARP37059_P050)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "48kDa".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "Foxa2 Antibody - C-terminal region (ARP37059_P050)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "FOXA2"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "FOXA2"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "FOXA2"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "FOXA2"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "FOXA2"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "FOXA2"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.