FOSB Polyclonal Antibody (OABB00432)

Catalog No: OABB00432 (Formerly GWB-BBP355)

Size:100UG

Lane 1: HT1080 Cell Lysate
Lane 2: SW620 Cell Lysate
Lane 3: Hela Cell Lysate
Lane 4: SMMC Cell Lysate
Lane 5: M453 Cell Lysate

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Hamster|Human|Mouse|Rat
• Product Format: Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
• Clonality: Polyclonal
• Clone: Polyclonal
• Isotype: Rabbit IgG
• Application: Western blot
• Additional Information: Notes: Tested Species: In-house tested species with positive results.
  Predicted Species: Species predicted to be fit for the product based on sequence similarities.
  Other applications have not been tested.
  Optimal dilutions should be determined by end users.
  
  Background: FOSB, FBJ murine osteosarcoma viral oncogene homolog B, is a protein that, in humans, is encoded by the FOSB gene. FOSB is a member of Fos gene family which consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. The FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. The FOSB gene is mapped to 19q13.32. Delta FOSB is a truncated splice variant of FOSB. Delta FosB has been implicated in the development of drug addiction and control of the reward system in the brain, and is linked to changes in a number of other gene products such as CREB and sirtuins. Delta FosB also regulates the commitment of mesenchymal precursor cells to the adipocyte or osteoblast lineage.
  Background: FOSB, FBJ murine osteosarcoma viral oncogene homolog B, is a protein that, in humans, is encoded by the FOSB gene. FOSB is a member of Fos gene family which consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. The FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. The FOSB gene is mapped to 19q13.32. Delta FOSB is a truncated splice variant of FOSB. Delta FosB has been implicated in the development of drug addiction and control of the reward system in the brain, and is linked to changes in a number of other gene products such as CREB and sirtuins. Delta FosB also regulates the commitment of mesenchymal precursor cells to the adipocyte or osteoblast lineage.
• Reconstitution and Storage: 2°C to 8°C|-20°C
• Immunogen: Polypeptide
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Human; Mouse; Rat
• Concentration: 500 ug/ml
• Specificity: No cross reactivity with other proteins.
• Application Info: Western blot: 0.1-0.5 ug/ml: Human: Mouse, Rat
• Reference: 1. Kelz, M. B., Chen, J., Carlezon, W. A., Jr., Whisler, K., Gilden, L., Beckmann, A. M., Steffen, C.,
  Zhang, Y.-J., Marotti, L., Self, D. W., Tkatch, T., Baranauskas, G., Surmeier, D. J., Neve, R. L.,
  Duman, R. S., Picciotto, M. R., Nestler, E. J.Expression of the transcription factor delta-FosB in the
  brain controls sensitivity to cocaine.Nature 401: 272-276, 1999.
  2. Martin-Gallardo, A., McCombie, W. R., Gocayne, J. D., FitzGerald, M. G., Wallace, S., Lee, B. M. B.,
  Lamerdin, J., Trapp, S., Kelley, J. M., Liu, L.-I., Dubnick, M., Johnston-Dow, L. A., Kerlavage, A. R.,
  de Jong, P., Carrano, A., Fields, C., Venter, J. C.Automated DNA sequencing and analysis of 106
  kilobases from human chromosome 19q13.3.Nature Genet. 1: 34-39, 1992.
  3. Nakabeppu, Y., Nathans, D.A naturally occurring truncated form of FosB that inhibits Fos/Jun
  transcriptional activity.Cell 64: 751-759, 1991.
• Storage Buffer: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
• Description: Rabbit IgG polyclonal antibody for Protein fosB(FOSB) detection. Tested with WB in Human;Mouse;Rat.

Target Info

• Gene Symbol: FOSB
• Gene Full Name: FosB proto-oncogene, AP-1 transcription factor subunit
• Alias Symbols: activator protein 1;AP-1;FBJ murine osteosarcoma viral oncogene homolog B;FosB proto-oncogene, AP-1 trancription factor subunit;G0/G1 switch regulatory protein 3;G0S3;GOS3;GOSB;protein fosB.
• NCBI Gene Id: 2354
• Protein Name: Protein fosB
• Description of Target: FosB interacts with Jun proteins enhancing their DNA binding activity.
• Uniprot ID: P53539
• Molecular Weight: 35928 MW