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| Datasheets/Manuals | Printable datasheet for FOLH1 Antibody (OASA03761) |
|---|
| Predicted Species Reactivity | Human |
|---|---|
| Product Format | Liquid. Phosphate buffered saline |
| Clonality | Monoclonal |
| Clone | GCP-04 |
| Isotype | IgG1 |
| Host | Mouse |
| Application | Immunohistochemistry-Paraffin|Western blot |
| Additional Information | Histology Positive Control Tissue: Human prostate, kidney or spinal cord. |
| :: | Preservative Stabilisers: 0.09% Sodium Azide (NaN3) |
| :: | Approx Protein Conc: IgG concentration 1.0mg/ml Buffer Solutions: Phosphate buffered saline |
| Reconstitution and Storage | -20°C |
| Immunogen | Recombinant fragment corresponding to amino acids 44-750 of human GCPII. |
| Purification | Protein A Purified |
| Predicted Homology Based on Immunogen Sequence | Human; Pig; Rat |
| Concentration | 1 mg/ml |
| Specificity | OASA03761 pecifically recognises amino acids 100-104 of the extracellular domain of prostate specific membrane antigen (PSMA), otherwise known as GCPII (glutamate carboxypeptidase II), a 95-110kDa type II transmembrane glycoprotein and member of the peptidase M28 family. Nomenclature for GCPII is dependent upon tissue specificity. PSMA is assigned to GCPII of prostate origin which is up-regulated in prostate cancer and a reliable diagnostic marker. Folate hydrolase (FOLH1) describes GCPII in the intestine and is required for folate uptake, whilst NAALADase refers to GCPII expressed in the central nervous system, which acts to cleave N-acetylaspartylglutamate (NAAG) to release glutamate, implicated in pathological conditions including Alzheimer’s and Huntington’s disease. |
| Application Info | IHC-FFPE: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.Sodium citrate buffer pH 6.0 is recommended for this purpose. |
| Reference | 1. Rovenska, M. et al. (2008) Tissue expression and enzymologic characterization of human prostate specific membrane antigen and its rat and pig orthologs. The Prostate. 68: 171-182. 2. Barinka, C. et al. (2004) Identification of the N-glycosylation sites on glutamate carboxypeptidase II necessary for proteolytic activity. Protein Sci. 13: 1627-1635. |
| Gene Symbol | FOLH1 |
|---|---|
| Alias Symbols | PSM, FGCP, FOLH, GCP2, PSMA, mGCP, GCPII, NAALAD1, NAALAdase |
| NCBI Gene Id | 2346 |
| Protein Name | Glutamate carboxypeptidase 2 |
| Description of Target | MOUSE ANTI PROSTATE SPECIFIC MEMBRANE ANTIGEN |
| Uniprot ID | Q04609 |
| Protein Accession # | NP_001014986.1 |
| Protein Size (# AA) | 719 |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "FOLH1 Antibody (OASA03761)"?
The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".
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How long will it take to receive "FOLH1 Antibody (OASA03761)"?
This item is available "Domestic: within 1-2 weeks delivery | International: 1-2 weeks".
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What buffer format is "FOLH1 Antibody (OASA03761)" provided in?
This item is provided in "Liquid. Phosphate buffered saline".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "FOLH1 Antibody (OASA03761)"?
This target may also be called "PSM, FGCP, FOLH, GCP2, PSMA, mGCP, GCPII, NAALAD1, NAALAdase" in publications.
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What is the shipping cost for "FOLH1 Antibody (OASA03761)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "FOLH1 Antibody (OASA03761)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "FOLH1 Antibody (OASA03761)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "FOLH1 Antibody (OASA03761)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "FOLH1"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "FOLH1"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "FOLH1"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "FOLH1"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "FOLH1"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "FOLH1"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.
