FLT4 Antibody (OAAB17750)

Catalog No: OAAB17750

Size:400ul

VEGFR3 Antibody (Cat. #OAAB17750) western blot analysis in 293 and A549 cell line lysates (35ug/lane).
This demonstrates the VEGFR3 antibody detected the VEGFR3 protein (arrow).
Dilution: 1:2000

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid. Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
• Clonality: Monoclonal
• Isotype: IgG2a
• Host: Mouse
• Application: WB
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: Purified His-tagged VEGFR3 protein was used to produced this monoclonal antibody.
• Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.
• Application Info: IHC-P: 1:25
  FC: 1:25
  WB: 1:2000
• Reference: Irrthum A., et al. Am. J. Hum. Genet. 67:295-301(2000).
  Pajusola K., et al. Cancer Res. 52:5738-5743(1992).
  Pajusola K., et al. Cancer Res. 53:3845-3845(1993).
  Galland F., et al. Genomics 13:475-478(1992).
  Galland F., et al. Oncogene 8:1233-1240(1993).

Target Info

• Gene Symbol: FLT4
• Alias Symbols: PCL, CHTD7, FLT-4, FLT41, LMPH1A, LMPHM1, VEGFR3, VEGFR-3
• NCBI Gene Id: 2324
• Description of Target: Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'.
• Uniprot ID: P35916
• Protein Accession #: NP_002011.2, NP_891555.2
• Molecular Weight: 146 kDa