FLK1 (VEGF-R2) Antibody (OAAD00154)

Catalog No: OAAD00154

Size:100 ug

Product Info

• Predicted Species Reactivity: Human
• Clonality: Monoclonal
• Clone: FLK-6
• Isotype: IgG1
• Host: Mouse
• Application: WB, IHC
• Reconstitution and Storage: At -20C for one year. After reconstitution, at 4C for one month. It can also be aliquotted and stored frozen at -20C for longer time.
• Immunogen: Recombinant human extracellular domain of VEGFR-2 (KDR).
• Purification: Purified by the goat anti-mouse IgG Affinity chromatography.
• Specificity: Human.
  No cross reactivity with other proteins.
• Formulation: Lyophilized from 1.2% sodium acetate, with 2mg BSA and 0.01mg NaN3 as preservative.
• Application Info: Western blot At 0.5-1ug/ml with the appropriate system to detect VEGFR2 in cells and tissues.
  Immunohistochemistry(F) At 1-2ug/ml to detect VEGFR2 in formalin or acetone fixed tissues.
  Other applications have not been tested.
  Optimal dilutions should be determined by end user.
• Storage Buffer: 1.2% sodium acetate or neutral PBS. If 1ml of PBS is used, the antibody concentration will be 100ug/ml.
• Reference: 1.Folkman, J. : Angiogenesis in cancer, vascular, rheumatoid and other disease. Nature Med. 1: 27-31, 1995.
  2.Millauer, B.; Shawver, L. K.; Plate, K. H.; Risau, W.; Ullrich, A. : Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant. Nature 367: 576-579, 1994.

Target Info

• Gene Symbol: KDR
• Alias Symbols: FLK1, CD309, VEGFR, VEGFR2
• NCBI Gene Id: 3791
• Protein Name: Vascular endothelial growth factor receptor 2
• Description of Target: VEGF, a homodimeric glycoprotein of relative molecular mass 45, 000, is the only mitogen that specifically acts on endothelial cells. The importance of VEGF and its receptor system in tumor growth and intervention in this system may provide promising approaches to cancer therapy. VEGF receptor 2 is a member of a receptor tyrosine kinase family.Like other growth factor receptors, upon ligand binding VEGF receptor 2 dimerises and is autophosphorylated on multiple tyrosine residues.
• Uniprot ID: P35968