Catalog No: ARP88501_P050
Price: $0.00
SKU
ARP88501_P050
Availability: Domestic: within 24 hours delivery | International: 3-5 days
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Datasheets/ManualsPrintable datasheet for anti-FIP1L1 (ARP88501_P050) antibody
Product Info
Tested Species ReactivityHuman
Predicted Species ReactivityHuman
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ClonalityPolyclonal
HostRabbit
ApplicationWB
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThe immunogen is a synthetic peptide directed towards the C terminal region of human FIP1L1
PurificationAffinity purified
Peptide SequenceSynthetic peptide located within the following region: RHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKEGKE
Concentration0.5 mg/ml
Blocking PeptideFor anti-FIP1L1 (ARP88501_P050) antibody is Catalog # AAP88501
Gene SymbolFIP1L1
Gene Full Namefactor interacting with PAPOLA and CPSF1
Alias SymbolsRhe, FIP1, hFip1
NCBI Gene Id81608
Protein Namepre-mRNA 3'-end-processing factor FIP1
Description of TargetThis gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Uniprot IDQ6UN15-5
Protein Accession #NP_001128409.1
Nucleotide Accession #NM_001134937.1
Protein Size (# AA)588
Molecular Weight64 kDa
  1. What is the species homology for "FIP1L1 Antibody - C-terminal region (ARP88501_P050)"?

    The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human".

  2. How long will it take to receive "FIP1L1 Antibody - C-terminal region (ARP88501_P050)"?

    This item is available "Domestic: within 24 hours delivery | International: 3-5 days".

  3. What buffer format is "FIP1L1 Antibody - C-terminal region (ARP88501_P050)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "FIP1L1 Antibody - C-terminal region (ARP88501_P050)"?

    This target may also be called "Rhe, FIP1, hFip1" in publications.

  5. What is the shipping cost for "FIP1L1 Antibody - C-terminal region (ARP88501_P050)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "FIP1L1 Antibody - C-terminal region (ARP88501_P050)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "FIP1L1 Antibody - C-terminal region (ARP88501_P050)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "64 kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "FIP1L1 Antibody - C-terminal region (ARP88501_P050)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "FIP1L1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "FIP1L1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "FIP1L1"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "FIP1L1"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "FIP1L1"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "FIP1L1"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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