Fingolimod (FTY-720) (OOMC00033)

Catalog No: OOMC00033

Product Info

• Product Format: Lyophilized
• Additional Information: Chemical Formula: C₁₉H₃₃NO₂• HCl
• Reconstitution and Storage: May be dissolved in DMSO (100 mg/ml) or ethanol (40 mg/ml, warm). Store desiccated as supplied at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
• Purity: > 98% (TL); NMR (conforms)
• Reference: 1) Brinkmann et al. (2002), The immune modulator FTY720 targets spingosine-1-phosphate receptors; J. Biol. Chem., 277 21453 2) Wolf et al. (2009), The sphingosine 1-phosphate receptor agonist FTY720 potently inhibits regulatory T cell proliferation in vitro and in vivo; J. Immunol., 183 3751 3) Awojoodu et al. (2013), Sphingosine 1-phosphate receptor 3 regulates recruitment of anti-inflammatory monocytes to microvessels during implant arteriogenesis; Proc. Natl. Acad. Sci. USA, 110 13785 4) Chiba (2005), FTY720, a new class of immunomodulator, inhibits lymphocyte egress from secondary lymphoid tissues and thymus by agonistic activity at sphingosine 1-phosphate receptors; Pharmacol. Ther., 108 308

Target Info

• Alias Symbols: Fingolimod
• Description of Target: An analog of sphingosine which, when taken up into cells, is phosphorylated and acts as an agonist at sphingosine-1-phosphate receptors (S1P1/3).
• Molecular Weight: 343.94 g/mol