Fibronectin Rat - Rat Fibronectin Protein (OOPA00193)

Catalog No: OOPA00193 (Formerly GWB-BSP482)

Size:20UG

Product Info

• Product Format: Sterile Filtered White lyophilized (freeze-dried) powder.
• Host: Rat Plasma.
• Additional Information: Solubility: Purified Rat fibronectin has a tendency to form insoluble aggregates upon reconstitution. We suggest reconstituting the 1mg Fibronectin with a chaotropic agent such as urea at room temperature at a concentration of 0.2mg/ml using sterile water. Let stand 1-2 hours.
  Product Introduction: Plasma fibronectin level is elevated in severe coronary artery disease. Increased plasma fibronectin levels are related with venous thromboembolism (VTE) particularly in males, and extend the probable association between biomarkers and risk factors for arterial atherothrombosis and VTE. Fibronectin plays a role in several cellular processes, including tissue repair, embryogenesis, blood clotting, and cell migration/adhesion. Fibronectin consists in two main forms: 1) as an insoluble glycoprotein dimer that serves as a linker in the etracellular matrix and 2) as a soluble disulphide linked dimer found in the plasma. The plasma form is produced by hepatocytes, and the ECM form is synthesized by fibroblasts, chondrocytes, endothelial cells, macrophages, as well as certain epithelial cells. Fibronectin alos takes part as a general cell adhesion molecule by anchoring cells to collagen or proteoglycan substrates. Fibronectin organizes cellular interaction with the ECM by binding to different components of the extracellular matrix and to membrane-bound Fibronectin receptors on cell surfaces. Molecular Weight 220kDa.
• Reconstitution and Storage: Store the lyophilized fibronectin at 4C. Upon reconstitution fibronectin should be stored at 4C for 2 weeks and for future use below -18C. Please prevent freeze-thaw cycles.
• Formulation: The Rat Fibronectin was lyophilized from a concentrated 1mg/ml solution containing 20mM Tris Cl pH-7.5.
• Purification: Greater than 95.0% as determined by SDS-PAGE.
• Purity: Greater than 95.0% as determined by SDS-PAGE.

Target Info

• Gene Symbol: Fibronectin