FHIT Antibody - C-terminal (OAPB01791)

Catalog No: OAPB01791

Size:100UG

Western blot analysis of FHIT in HeLa cell lysate with FHIT antibody at (A) 1 and (B) 2 ug/ml.

Product Info

• Predicted Species Reactivity: Bovine|Human|Mouse|Rat
• Product Format: Liquid. FHIT Antibody is supplied in PBS containing 0.02% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Immunofluorescence|Western blot
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: FHIT antibody was raised against an 18 amino acid peptide near the carboxy terminus of human FHIT. The immunogen is located within the last 50 amino acids of FHIT .
• Purification: Affinity Purified
• Concentration: 1 mg/ml

Target Info

• Gene Symbol: FHIT
• Gene Full Name: fragile histidine triad diadenosine triphosphatase
• Alias Symbols: AP3A hydrolase;AP3Aase;bis(5'-adenosyl)-triphosphatase;diadenosine 5',5'''-P1,P3-triphosphate hydrolase;dinucleosidetriphosphatase;FRA3B;Fragile histidine triad protein.
• NCBI Gene Id: 2272
• Protein Name: Bis(5'-adenosyl)-triphosphatase|bis(5'-adenosyl)-triphosphatase isoform 1 [Homo sapiens]
• Description of Target: Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity, it may in part come from the mitochondrial form, which sensitizes the low-affinity Ca(2+) transporters, enhancing mitochondrial calcium uptake. Functions as tumor suppressor.
• Uniprot ID: P49789
• Protein Accession #: https://www.ncbi.nlm.nih.gov/protein/NP_002003
• Nucleotide Accession #: NM_001166243.2
• Molecular Weight: Predicted: 16 kDa Observed: 15kDa