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FGR Antibody - N-terminal region (OAAB17222)

400ul
$390.00
In Stock
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Gene Symbol:
FGR
NCBI Gene Id:
2268
Protein Name:
Tyrosine-protein kinase Fgr
Swissprot Id:
P09769
Protein Accession #:
NP_001036194.1
Alias Symbols:
FGR, SRC2, Tyrosine-protein kinase Fgr, Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, Proto-oncogene c-Fgr, p55-Fgr, p58-Fgr, p58c-Fgr
Replacement Item:
This antibody may replace item sc-130 from Santa Cruz Biotechnology.
Description of Target:
Purified Rabbit Polyclonal Antibody (Pab)
Molecular Weight:
59479 Da
Host:
Rabbit
Clonality:
Polyclonal
Application:
WB, IHC, IF
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express FGR.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express FGR.
Immunogen:
This FGR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 3-33 amino acids from the N-terminal region of human FGR.
Predicted Species Reactivity:
Human
Predicted Homology Based on Immunogen Sequence:
Human
Product Format:
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Reconstitution and Storage:
Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Approximately 0.5mg/ml. Actual concentration varies with each lot.
Datasheets/Manuals:
Printable datasheet for OAAB17222
Isotype:
Ig
Application Info:
WB: 1:2000
WB: 1:1000
IHC-P: 1:50~100
IF: 1:10~50
Additional Information:
Precautions: FGR Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
:::
Function: Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion Depending on the context, activates or inhibits cellular responses. Functions as negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK- dependent activation of AKT1 and MAP kinase signaling Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1
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Cellular Location: Cell membrane; Lipid-anchor; Cytoplasmic side (Probable). Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle membrane. Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Mitochondrion inner membrane (By similarity). Mitochondrion intermembrane space (By similarity) Note=Detected in mitochondrial intermembrane space and at inner membranes (By similarity). Colocalizes wi
Tissue Location: Detected in neutrophils, monocytes and natural killer cells (at protein level). Detected in monocytes and large lymphocytes

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