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- $55: Antibody & Protein in US
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Datasheets/Manuals | Printable datasheet for FGFR1 Antibody (OAAF00766) |
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Predicted Species Reactivity | Human|Mouse|Rat |
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Product Format | Liquid PBS (without Mg2+ and Ca2+) (pH 7.4), 150mM NaCl, 0.02% sodium azide and 50% glycerol |
Clonality | Polyclonal |
Isotype | IgG |
Host | Rabbit |
Application | Enzyme-linked immunosorbent assay|Immunocytochemistry|Immunofluorescence|Western blot |
Reconstitution and Storage | -20°C |
Immunogen | The antiserum was produced against synthesized peptide derived from human FGFR1. |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration | 1 mg/ml |
Specificity | FGFR1 (Ab-654) antibody detects endogenous levels of total FGFR1 protein. |
Dilution | The optimal working dilution should be determined by the end user. |
Application Info | WB: 1:500~1000 IF: 1:100~500 ELISA: 1:1000 |
Reference | Chitta S. Kasyapa, Blood, May 2006; 107: 3693 - 3699. Benoit Rousseau, Cancer Res., Apr 2004; 64: 2490 - 2495. Takayuki Nakayama, Blood, Feb 2007; 109: 1363 - 1372. Qing Wang, Development, Oct 2001; 128: 3867. |
Gene Symbol | FGFR1 |
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Gene Full Name | fibroblast growth factor receptor 1 |
Alias Symbols | basic fibroblast growth factor receptor 1;BFGFR;bFGF-R-1;CD331;CEK;ECCL;FGFBR;FGFR-1;FGFR1/PLAG1 fusion;fibroblast growth factor receptor 1;FLG;FLT2;FLT-2;FMS-like tyrosine kinase 2;fms-related tyrosine kinase 2;HBGFR;heparin-binding growth factor receptor;HH2;HRTFDS;hydroxyaryl-protein kinase;KAL2;N-SAM;OGD;proto-oncogene c-Fgr. |
NCBI Gene Id | 2260 |
Protein Name | Fibroblast growth factor receptor 1 |
Description of Target | Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation. |
Uniprot ID | P11362 |
Protein Accession # | NP_001167534.1 |
Molecular Weight | 91 kDa |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "FGFR1 Antibody (OAAF00766)"?
The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human|Mouse|Rat".
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How long will it take to receive "FGFR1 Antibody (OAAF00766)"?
This item is available "Domestic: within 1-2 week delivery | International: 1-2 weeks".
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What buffer format is "FGFR1 Antibody (OAAF00766)" provided in?
This item is provided in "Liquid PBS (without Mg2+ and Ca2+) (pH 7.4), 150mM NaCl, 0.02% sodium azide and 50% glycerol ".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "FGFR1 Antibody (OAAF00766)"?
This target may also be called "basic fibroblast growth factor receptor 1;BFGFR;bFGF-R-1;CD331;CEK;ECCL;FGFBR;FGFR-1;FGFR1/PLAG1 fusion;fibroblast growth factor receptor 1;FLG;FLT2;FLT-2;FMS-like tyrosine kinase 2;fms-related tyrosine kinase 2;HBGFR;heparin-binding growth factor receptor;HH2;HRTFDS;hydroxyaryl-protein kinase;KAL2;N-SAM;OGD;proto-oncogene c-Fgr." in publications.
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What is the shipping cost for "FGFR1 Antibody (OAAF00766)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "FGFR1 Antibody (OAAF00766)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "FGFR1 Antibody (OAAF00766)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "91 kDa".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "FGFR1 Antibody (OAAF00766)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "FGFR1"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "FGFR1"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "FGFR1"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "FGFR1"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "FGFR1"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "FGFR1"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.