FGFR1 Antibody - N-terminal region (ARP86807_P050)

Catalog No: ARP86807_P050

Host: Rabbit
Target Name: FGFR1
Sample Tissue: Human A549 Whole Cell lysates
Antibody Dilution: 1ug/ml

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of Human FGFR1
• Purification: Affinity purified
• Peptide Sequence: Synthetic peptide located within the following region: VTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPV
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-FGFR1 (ARP86807_P050) antibody is Catalog # AAP86807

Target Info

• Gene Symbol: FGFR1
• Gene Full Name: fibroblast growth factor receptor 1
• Alias Symbols: CEK, FLG, HH2, OGD, ECCL, FLT2, KAL2, BFGFR, CD331, FGFBR, FLT-2, HBGFR, N-SAM, FGFR-1, HRTFDS, bFGF-R-1
• NCBI Gene Id: 2260
• Protein Name: Fibroblast growth factor receptor 1
• Description of Target: The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
• Uniprot ID: P11362-18
• Protein Accession #: NP_001167534.1
• Nucleotide Accession #: NM_001174063.1
• Protein Size (# AA): 300
• Molecular Weight: 33 kDa