FGF10 Polyclonal Antibody (OABB00408)

Catalog No: OABB00408 (Formerly GWB-BBP331)

Size:100UG

Lane 1: U87 Cell Lysate
Lane 2: Hela Cell Lysate
Lane 3: A519 Cell Lysate
Lane 4: 293T Cell Lysate
Lane 5: Hela Cell Lysate

Product Info

• Tested Species Reactivity: Human, Rat
• Predicted Species Reactivity: Hamster|Human|Mouse|Rat
• Product Format: Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
• Clonality: Polyclonal
• Clone: Polyclonal
• Isotype: Rabbit IgG
• Application: Western blot
• Additional Information: Notes: Tested Species: In-house tested species with positive results.
  Predicted Species: Species predicted to be fit for the product based on sequence similarities.
  Other applications have not been tested.
  Optimal dilutions should be determined by end users.
  
  Background: FGF 10, Fibroblast growth factor 10, is a protein that in humans is encoded by the FGF10 gene.The protein encoded by this gene is a member of the fibroblast growth factor(FGF) family. FGF 10 contains 3 exons and spans at least 52.7 kb. By radioactive in situ hybridization, the FGF 10 gene is mapped to 5p13-p12. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts. FGF 10 translocated into urothelial cell nuclei and initiated a signaling cascade that began with the heparin-dependent tyrosine phosphorylation of surface transmembrane receptors.
  Background: FGF 10, Fibroblast growth factor 10, is a protein that in humans is encoded by the FGF10 gene.The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF 10 contains 3 exons and spans at least 52.7 kb. By radioactive in situ hybridization, the FGF 10 gene is mapped to 5p13-p12. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts. FGF 10 translocated into urothelial cell nuclei and initiated a signaling cascade that began with the heparin-dependent tyrosine phosphorylation of surface transmembrane receptors.
• Reconstitution and Storage: 2°C to 8°C|-20°C
• Immunogen: Polypeptide
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Human; Mouse; Rat
• Concentration: 500 ug/ml
• Specificity: No cross reactivity with other proteins.
• Application Info: Western blot: 0.1-0.5 ug/ml: Human, Rat: Mouse
• Reference: 1. Bagai, S., Rubio, E., Cheng, J.-F., Sweet, R., Thomas, R., Fuchs, E., Grady, R., Mitchell, M., Bassuk,
  J. A.Fibroblast growth factor-10 is a mitogen for urothelial cells.J. Biol. Chem. 277: 23828-23837,
  2002.
  2. Emoto, H., Tagashira, S., Mattei, M.-G., Yamasaki, M., Hashimoto, G., Katsumata, T., Negoro, T.,
  Nakatsuka, M., Birnbaum, D., Coulier, F., Itoh, N.Structure and expression of human fibroblast
  growth factor-10.J. Biol. Chem. 272: 23191-23194, 1997.
  3. Umemori, H., Linhoff, M. W., Ornitz, D. M., Sanes, J. R.FGF22 and its close relatives are
  presynaptic organizing molecules in the mammalian brain.Cell 118: 257-270, 2004
• Storage Buffer: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
• Description: Rabbit IgG polyclonal antibody for Fibroblast growth factor 10(FGF10) detection. Tested with WB in Human;Mouse;Rat.

Target Info

• Gene Symbol: FGF10
• Gene Full Name: fibroblast growth factor 10
• Alias Symbols: FGF-10;fibroblast growth factor 10;keratinocyte growth factor 2;produced by fibroblasts of urinary bladder lamina propria.
• NCBI Gene Id: 2255
• Protein Name: Fibroblast growth factor 10
• Description of Target: Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing.
• Uniprot ID: O15520
• Molecular Weight: 23436 MW