FGD1 Antibody - N-terminal region : FITC (ARP38472_P050-FITC)

Catalog No: ARP38472_P050-FITC

Size:100ul

Product Info

• Predicted Species Reactivity: Human, Rat, Cow, Pig
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer.
• Clonality: Polyclonal
• Host: Rabbit
• Conjugation: FITC: Fluorescein Isothiocyanate
• Application: WB
• Reconstitution and Storage: All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human FGD1
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 86%; Human: 100%; Pig: 86%; Rat: 79%
• Peptide Sequence: Synthetic peptide located within the following region: HGHRAPGGAGPSEPEHPATNPPGAAPPACADSDPGASEPGLLARRGSGSA
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-FGD1 (ARP38472_P050-FITC) antibody is Catalog # AAP38472 (Previous Catalog # AAPP23401)
• Reference: Bottani,A., (2007) Am. J. Med. Genet. A 143A (19), 2334-2338
• Publications:

  Zou, W. et al. MLK3 regulates bone development downstream of the faciogenital dysplasia protein FGD1 in mice. J. Clin. Invest. 121, 4383-92 (2011). WB, Human, Bovine, Pig, Rat 21965325

Target Info

• Gene Symbol: FGD1
• Gene Full Name: FYVE, RhoGEF and PH domain containing 1
• Alias Symbols: AAS, FGDY, MRXS16, ZFYVE3
• NCBI Gene Id: 2245
• Protein Name: FYVE, RhoGEF and PH domain-containing protein 1
• Description of Target: FGD1 contains Dbl (DH) and pleckstrin (PH) homology domains. It can bind specifically to the Rho family GTPase Cdc42Hs and stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. FGD1 has an essential role in embryonic development, and FGD1 gene mutations result in the human developmental disorder, Aarskog-Scott syndrome.FGD1 contains Dbl (DH) and pleckstrin (PH) homology domains. It can bind specifically to the Rho family GTPase Cdc42Hs and stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. FGD1 has an essential role in embryonic development, and FGD1 gene mutations result in the human developmental disorder, Aarskog-Scott syndrome. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
• Uniprot ID: P98174
• Protein Accession #: NP_004454
• Nucleotide Accession #: NM_004463
• Protein Size (# AA): 961
• Molecular Weight: 106kDa
• Protein Interactions: BTRC; UBC; ELAVL1; ELMO1; CTTN; CDC42; AOC1;