- Gene Symbol:
- FGD1
- Official Gene Full Name:
- FYVE, RhoGEF and PH domain containing 1
- NCBI Gene Id:
- 2245
- Protein Name:
- FYVE, RhoGEF and PH domain-containing protein 1
- Swissprot Id:
- P98174
- Protein Accession #:
- NP_004454
- Nucleotide Accession #:
- NM_004463
- Alias Symbols:
- AAS, FGDY, ZFYVE3, MRXS16
- Replacement Item:
- This antibody may replace item sc-11109 from Santa Cruz Biotechnology.
- Description of Target:
- FGD1 contains Dbl (DH) and pleckstrin (PH) homology domains. It can bind specifically to the Rho family GTPase Cdc42Hs and stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. FGD1 has an essential role in embryonic development, and FGD1 gene mutations result in the human developmental disorder, Aarskog-Scott syndrome.FGD1 contains Dbl (DH) and pleckstrin (PH) homology domains. It can bind specifically to the Rho family GTPase Cdc42Hs and stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. FGD1 has an essential role in embryonic development, and FGD1 gene mutations result in the human developmental disorder, Aarskog-Scott syndrome. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
- Protein Size (# AA):
- 961
- Molecular Weight:
- 106kDa
- Host:
- Rabbit
- Clonality:
- Polyclonal
- Purification:
- Affinity Purified
- Application:
- WB
- Tissue Tool:
- Find tissues and cell lines supported by DNA array analysis to express FGD1.
- RNA Seq:
- Find tissues and cell lines supported by RNA-seq analysis to express FGD1.
- Immunogen:
- The immunogen is a synthetic peptide directed towards the N terminal region of human FGD1
- Predicted Species Reactivity:
- Cow, Human, Pig, Rat
- Tested Species Reactivity:
- Human
- Predicted Homology Based on Immunogen Sequence:
- Cow: 86%; Human: 100%; Pig: 86%; Rat: 79%
- Complete computational species homology data:
- Anti-FGD1 (ARP38472_P050)
- Peptide Sequence:
- Synthetic peptide located within the following region: HGHRAPGGAGPSEPEHPATNPPGAAPPACADSDPGASEPGLLARRGSGSA
- Product Format:
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
- Reconstitution and Storage:
- For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
- Concentration:
- Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
- Protein Interactions:
- BTRC; UBC; ELAVL1; ELMO1; CTTN; CDC42; AOC1;
- Blocking Peptide:
- For anti-FGD1 (ARP38472_P050) antibody is Catalog # AAP38472 (Previous Catalog # AAPP23401)
- Datasheets/Manuals:
- Printable datasheet for anti-FGD1 (ARP38472_P050) antibody
- Target Reference:
- Bottani,A., (2007) Am. J. Med. Genet. A 143A (19), 2334-2338
- Publications:
Zou, W. et al. MLK3 regulates bone development downstream of the faciogenital dysplasia protein FGD1 in mice. J. Clin. Invest. 121, 4383-92 (2011). WB, Cow, Human, Pig, Rat 21965325
Product Reviews
- Protocol:
- Tips Information:
See our General FAQ page.
TO ORDER:
Phone: (888) 880-0001
Fax: (858) 552-6975
Top Products For FGD1:
Human HeartFGD1 Antibody - C-terminal region (ARP31673_P050)Application: IHC, WBSpecies: Cow, Dog, Horse, Human, Mouse, Pig, Rabbit, Rat |
Recent Reviews
-
HEK293 cells, primary mouse hippocampal cells in WBUniversity of Heidelberg, Germany