Size:100 ul
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ARP38472_P050
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Conjugation Options

ARP38472_P050-FITC Conjugated

ARP38472_P050-HRP Conjugated

ARP38472_P050-Biotin Conjugated

FGD1 Antibody - N-terminal region (ARP38472_P050)

Catalog#: ARP38472_P050
Domestic: within 1-2 days delivery International: 1-2 days
More Information
Tested Species Reactivity Human
Predicted Species Reactivity Cow, Human, Pig, Rat
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Clonality Polyclonal
Host Rabbit
Application WB
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Replacement Item This antibody may replace item sc-11109 from Santa Cruz Biotechnology.
Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human FGD1
Purification Affinity Purified
Predicted Homology Based on Immunogen Sequence Cow: 86%; Human: 100%; Pig: 86%; Rat: 79%
Complete computational species homology data Anti-FGD1 (ARP38472_P050)
Peptide Sequence Synthetic peptide located within the following region: HGHRAPGGAGPSEPEHPATNPPGAAPPACADSDPGASEPGLLARRGSGSA
Concentration Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Blocking Peptide For anti-FGD1 (ARP38472_P050) antibody is Catalog # AAP38472 (Previous Catalog # AAPP23401)
Datasheets/Manuals Printable datasheet for anti-FGD1 (ARP38472_P050) antibody
Target Reference Bottani,A., (2007) Am. J. Med. Genet. A 143A (19), 2334-2338
Publications

Zou, W. et al. MLK3 regulates bone development downstream of the faciogenital dysplasia protein FGD1 in mice. J. Clin. Invest. 121, 4383-92 (2011). WB, Cow, Human, Pig, Rat 21965325

Gene Symbol FGD1
Official Gene Full Name FYVE, RhoGEF and PH domain containing 1
Alias Symbols AAS, FGDY, ZFYVE3, MRXS16
NCBI Gene Id 2245
Protein Name FYVE, RhoGEF and PH domain-containing protein 1
Description of Target FGD1 contains Dbl (DH) and pleckstrin (PH) homology domains. It can bind specifically to the Rho family GTPase Cdc42Hs and stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. FGD1 has an essential role in embryonic development, and FGD1 gene mutations result in the human developmental disorder, Aarskog-Scott syndrome.FGD1 contains Dbl (DH) and pleckstrin (PH) homology domains. It can bind specifically to the Rho family GTPase Cdc42Hs and stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. FGD1 has an essential role in embryonic development, and FGD1 gene mutations result in the human developmental disorder, Aarskog-Scott syndrome. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Swissprot Id P98174
Protein Accession # NP_004454
Nucleotide Accession # NM_004463
Protein Size (# AA) 961
Molecular Weight 106kDa
Tissue Tool Find tissues and cell lines supported by DNA array analysis to express FGD1.
RNA Seq Find tissues and cell lines supported by RNA-seq analysis to express FGD1.
Protein Interactions BTRC; UBC; ELAVL1; ELMO1; CTTN; CDC42; AOC1;
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