Size:100 ul
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ARP38472_P050
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Conjugation Options

ARP38472_P050-FITC Conjugated

ARP38472_P050-HRP Conjugated

ARP38472_P050-Biotin Conjugated

FGD1 Antibody - N-terminal region (ARP38472_P050)

Catalog#: ARP38472_P050
Domestic: within 1-2 days delivery | International: 1-2 days
More Information
Tested Species Reactivity Human
Predicted Species Reactivity Cow, Human, Pig, Rat
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Clonality Polyclonal
Host Rabbit
Application WB
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Replacement Item This antibody may replace item sc-11109 from Santa Cruz Biotechnology.
Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human FGD1
Purification Affinity Purified
Predicted Homology Based on Immunogen Sequence Cow: 86%; Human: 100%; Pig: 86%; Rat: 79%
Complete computational species homology data Anti-FGD1 (ARP38472_P050)
Peptide Sequence Synthetic peptide located within the following region: HGHRAPGGAGPSEPEHPATNPPGAAPPACADSDPGASEPGLLARRGSGSA
Concentration Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Blocking Peptide For anti-FGD1 (ARP38472_P050) antibody is Catalog # AAP38472 (Previous Catalog # AAPP23401)
Datasheets/Manuals Printable datasheet for anti-FGD1 (ARP38472_P050) antibody
Target Reference Bottani,A., (2007) Am. J. Med. Genet. A 143A (19), 2334-2338
Publications

Zou, W. et al. MLK3 regulates bone development downstream of the faciogenital dysplasia protein FGD1 in mice. J. Clin. Invest. 121, 4383-92 (2011). WB, Cow, Human, Pig, Rat 21965325

Gene Symbol FGD1
Official Gene Full Name FYVE, RhoGEF and PH domain containing 1
Alias Symbols AAS, FGDY, ZFYVE3, MRXS16
NCBI Gene Id 2245
Protein Name FYVE, RhoGEF and PH domain-containing protein 1
Description of Target FGD1 contains Dbl (DH) and pleckstrin (PH) homology domains. It can bind specifically to the Rho family GTPase Cdc42Hs and stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. FGD1 has an essential role in embryonic development, and FGD1 gene mutations result in the human developmental disorder, Aarskog-Scott syndrome.FGD1 contains Dbl (DH) and pleckstrin (PH) homology domains. It can bind specifically to the Rho family GTPase Cdc42Hs and stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. FGD1 has an essential role in embryonic development, and FGD1 gene mutations result in the human developmental disorder, Aarskog-Scott syndrome. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Swissprot Id P98174
Protein Accession # NP_004454
Nucleotide Accession # NM_004463
Protein Size (# AA) 961
Molecular Weight 106kDa
Tissue Tool Find tissues and cell lines supported by DNA array analysis to express FGD1.
RNA Seq Find tissues and cell lines supported by RNA-seq analysis to express FGD1.
Protein Interactions BTRC; UBC; ELAVL1; ELMO1; CTTN; CDC42; AOC1;
  1. What is the species homology for "FGD1 Antibody - N-terminal region (ARP38472_P050)"?

    The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Cow, Human, Pig, Rat".

  2. How long will it take to receive "FGD1 Antibody - N-terminal region (ARP38472_P050)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "FGD1 Antibody - N-terminal region (ARP38472_P050)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "FGD1 Antibody - N-terminal region (ARP38472_P050)"?

    This target may also be called "AAS, FGDY, ZFYVE3, MRXS16" in publications.

  5. What is the shipping cost for "FGD1 Antibody - N-terminal region (ARP38472_P050)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "FGD1 Antibody - N-terminal region (ARP38472_P050)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "FGD1 Antibody - N-terminal region (ARP38472_P050)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "106kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "FGD1 Antibody - N-terminal region (ARP38472_P050)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data tab on the product page.

  10. What are positive controls for "FGD1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "FGD1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "FGD1"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "FGD1"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "FGD1"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "FGD1"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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