Search Antibody, Protein, and ELISA Kit Solutions

FGD1 Antibody - N-terminal region (ARP38472_P050)

100 ul
$289.00
In Stock
Request Bulk Order Quote

Conjugation Options

ARP38472_P050-FITC Conjugated

ARP38472_P050-HRP Conjugated

ARP38472_P050-Biotin Conjugated

Gene Symbol:
FGD1
Official Gene Full Name:
FYVE, RhoGEF and PH domain containing 1
NCBI Gene Id:
2245
Protein Name:
FYVE, RhoGEF and PH domain-containing protein 1
Swissprot Id:
P98174
Protein Accession #:
NP_004454
Nucleotide Accession #:
NM_004463
Alias Symbols:
AAS, FGDY, ZFYVE3, MRXS16
Replacement Item:
This antibody may replace item sc-11109 from Santa Cruz Biotechnology.
Description of Target:
FGD1 contains Dbl (DH) and pleckstrin (PH) homology domains. It can bind specifically to the Rho family GTPase Cdc42Hs and stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. FGD1 has an essential role in embryonic development, and FGD1 gene mutations result in the human developmental disorder, Aarskog-Scott syndrome.FGD1 contains Dbl (DH) and pleckstrin (PH) homology domains. It can bind specifically to the Rho family GTPase Cdc42Hs and stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. FGD1 has an essential role in embryonic development, and FGD1 gene mutations result in the human developmental disorder, Aarskog-Scott syndrome. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Protein Size (# AA):
961
Molecular Weight:
106kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Affinity Purified
Application:
WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express FGD1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express FGD1.
Immunogen:
The immunogen is a synthetic peptide directed towards the N terminal region of human FGD1
Predicted Species Reactivity:
Cow, Human, Pig, Rat
Tested Species Reactivity:
Human
Predicted Homology Based on Immunogen Sequence:
Cow: 86%; Human: 100%; Pig: 86%; Rat: 79%
Complete computational species homology data:
Anti-FGD1 (ARP38472_P050)
Peptide Sequence:
Synthetic peptide located within the following region: HGHRAPGGAGPSEPEHPATNPPGAAPPACADSDPGASEPGLLARRGSGSA
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
BTRC; UBC; ELAVL1; ELMO1; CTTN; CDC42; AOC1;
Blocking Peptide:
For anti-FGD1 (ARP38472_P050) antibody is Catalog # AAP38472 (Previous Catalog # AAPP23401)
Datasheets/Manuals:
Printable datasheet for anti-FGD1 (ARP38472_P050) antibody
Target Reference:
Bottani,A., (2007) Am. J. Med. Genet. A 143A (19), 2334-2338
Publications:

Zou, W. et al. MLK3 regulates bone development downstream of the faciogenital dysplasia protein FGD1 in mice. J. Clin. Invest. 121, 4383-92 (2011). WB, Cow, Human, Pig, Rat 21965325

Product Reviews

Tell us what you think about this item!

Write A Review
    Please, wait...