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FGA Antibody - middle region (ARP41759_P050)

100 ul
$319.00
In Stock
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Conjugation Options

ARP41759_P050-FITC Conjugated

ARP41759_P050-HRP Conjugated

ARP41759_P050-Biotin Conjugated

Gene Symbol:
FGA
Official Gene Full Name:
Fibrinogen alpha chain
NCBI Gene Id:
2243
Protein Name:
Fibrinogen alpha chain
Swissprot Id:
Q4QQH7
Protein Accession #:
NP_068657
Nucleotide Accession #:
NM_021871
Alias Symbols:
Fib2, MGC119422, MGC119423, MGC119425
Replacement Item:
This antibody may replace item sc-166968 from Santa Cruz Biotechnology.
Description of Target:
FGA is the alpha component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in its gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. The protein encoded by this gene is the alpha component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in two isoforms which vary in the carboxy-terminus.
Protein Size (# AA):
644
Molecular Weight:
66kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Affinity Purified
Application:
WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express FGA.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express FGA.
Immunogen:
The immunogen is a synthetic peptide directed towards the middle region of human FGA
Predicted Species Reactivity:
Human
Tested Species Reactivity:
Human
Predicted Homology Based on Immunogen Sequence:
Human: 100%
Complete computational species homology data:
Anti-FGA (ARP41759_P050)
Peptide Sequence:
Synthetic peptide located within the following region: SSSYSKQFTSSTSYNRGDSTFESKSYKMADEAGSEADHEGTHSTKRGHAK
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
ASB7; ASB6; FN1; APOA1; ALB; UBC; SUMO2; MIS12; KHDRBS2; ITGA2B; SERPINA5; CDH5; SERPINF2; THBS1; F2; ITGB3; PLAT; HRG; PRRC2A; FGG; FGB; FGA; F13A1; NID1;
Blocking Peptide:
For anti-FGA (ARP41759_P050) antibody is Catalog # AAP41759 (Previous Catalog # AAPP10807)
Datasheets/Manuals:
Printable datasheet for anti-FGA (ARP41759_P050) antibody
Target Reference:
Jood,K., (2008) J. Thromb. Haemost. 6 (6), 897-904
Publications:

Matsumoto, M. et al. An efficient system for secretory production of fibrinogen using a hepatocellular carcinoma cell line. Hepatol. Res. 45, 315-25 (2015). WB, Human 24802089

Prieto-García, A. et al. Mast cell restricted mouse and human tryptase·heparin complexes hinder thrombin-induced coagulation of plasma and the generation of fibrin by proteolytically destroying fibrinogen. J. Biol. Chem. 287, 7834-44 (2012). WB, Human 22235124

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