Size:100 ul
$249.00
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SKU
ARP41682_T100
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Conjugation Options

ARP41682_T100-FITC Conjugated

ARP41682_T100-HRP Conjugated

ARP41682_T100-Biotin Conjugated

FECH Antibody - N-terminal region (ARP41682_T100)

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Catalog#: ARP41682_T100
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More Information
Tested Species Reactivity Human, Mouse
Predicted Species Reactivity Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Yeast, Zebrafish
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Clonality Polyclonal
Host Rabbit
Application WB
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human FECH
Purification Protein A purified
Predicted Homology Based on Immunogen Sequence Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 77%; Zebrafish: 86%
Complete computational species homology data Anti-FECH (ARP41682_T100)
Peptide Sequence Synthetic peptide located within the following region: LDRDLMTLPIQNKLAPFIAKRRTPKIQEQYRRIGGGSPIKIWTSKQGEGM
Concentration Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Blocking Peptide For anti-FECH (ARP41682_T100) antibody is Catalog # AAP41682 (Previous Catalog # AAPP24325)
Datasheets/Manuals Printable datasheet for anti-FECH (ARP41682_T100) antibody
Sample Type Confirmation

FECH is strongly supported by BioGPS gene expression data to be expressed in Jurkat

Target Reference Maruyama,K. (2005) Blood 106 (3), 1098-1104
Publications

Miyake, M. et al. siRNA-mediated knockdown of the heme synthesis and degradation pathways: modulation of treatment effect of 5-aminolevulinic acid-based photodynamic therapy in urothelial cancer cell lines. Photochem. Photobiol. 85, 1020-7 (2009). WB, Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Yeast, Zebrafish 19320847

Gene Symbol FECH
Official Gene Full Name Ferrochelatase
Alias Symbols EPP, FCE
NCBI Gene Id 2235
Protein Name Ferrochelatase, mitochondrial
Description of Target Ferrochelatase is localized to the mitochondrion where it catalyzes the insertion of the ferrous form of iron into protoporphyrin IX in the heme synthesis pathway. Defects in ferrochelatase are associated with protoporphyria.Ferrochelatase is localized to the mitochondrion where it catalyzes the insertion of the ferrous form of iron into protoporphyrin IX in the heme synthesis pathway. Defects in ferrochelatase are associated with protoporphyria. Two transcript variants encoding different isoforms have been found for this gene.
Swissprot Id Q8NAN0
Protein Accession # NP_001012533
Nucleotide Accession # NM_001012515
Protein Size (# AA) 429
Molecular Weight 47kDa
Tissue Tool Find tissues and cell lines supported by DNA array analysis to express FECH.
RNA Seq Find tissues and cell lines supported by RNA-seq analysis to express FECH.
Protein Interactions PPP2R1A; UBC; NEDD8; MDM2; FBXO6; gag-pol; COPS5; COPS6; CUL3; ELAVL1; MINOS1; MME; USP42; USP20; ABCB7; FECH;
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