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Now Offering Over 102,157 Antibodies & 44,722 Antigens!

FBXW7 Antibody - C-terminal region (ARP47419_P050)

100 ul
$319.00
In Stock

Conjugation Options

ARP47419_P050-FITC Conjugated

ARP47419_P050-HRP Conjugated

ARP47419_P050-Biotin Conjugated

Gene Symbol:
FBXW7
NCBI Gene Id:
55294
Official Gene Full Name:
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
Protein Name:
F-box/WD repeat-containing protein 7
Swissprot Id:
Q969H0-4
Protein Accession #:
NP_001013433
Nucleotide Accession #:
NM_001013415
Alias Symbols:
AGO, CDC4, FBW6, FBW7, FBX30, FBXO30, FBXW6, SEL-10, SEL10, hAgo, hCdc4
Replacement Item:
This antibody may replace item sc-133448 from Santa Cruz Biotechnology.
Description of Target:
FBXW7 is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in FBXW7 gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers.
Protein Size (# AA):
707
Molecular Weight:
80kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Affinity Purified
Application:
IHC, WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis
Immunogen:
The immunogen is a synthetic peptide directed towards the C-terminal region of Human FBXW7
Species Reactivity:
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
Predicted Homology Based on Immunogen Sequence:
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
Complete computational species homology data:
ARP47419_P050
Peptide Sequence:
Synthetic peptide located within the following region: LKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRNGTEETKLLVL
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
MCL1; CDC34; CCNE1; FBXW7; CUL1; UBE2D1; PIN1; DAB2IP; YAP1; SKP1; MAP4K1; EYA1; KLF5; SREBF1; NOTCH1; UBE2QL1; Creb3l2; Creb3l1; SIC1; CSF3R; KLF2; NCOA3; PTEN; NFE2L1; HSP90AA1; MED11; MED19; MED8; MED30; MED10; MED28; MED29; MED9; MED15; MED31; MED4; M
Blocking Peptide:
Catalog # AAP47419
Datasheets/Manuals:
Printable datasheet for ARP47419_P050
Sample Type Confirmation:

FBXW7 is supported by BioGPS gene expression data to be expressed in Jurkat

Additional Information:
IHC Information: Paraffin embedded kidney tissue, tested with an antibody dilution of 2.5 ug/ml.
Publications:

Gong, Y. et al. Pan-cancer genetic analysis identifies PARK2 as a master regulator of G1/S cyclins. Nat. Genet. 46, 588-94 (2014). IHC, WB, Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish 24793136

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