Size:100 ul
$319.00
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SKU
ARP47419_P050
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Conjugation Options

ARP47419_P050-FITC Conjugated

ARP47419_P050-HRP Conjugated

ARP47419_P050-Biotin Conjugated

More Information
Tested Species Reactivity Human
Predicted Species Reactivity Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Clonality Polyclonal
Host Rabbit
Application IHC, WB
Additional Information IHC Information: Paraffin embedded kidney tissue, tested with an antibody dilution of 2.5 ug/ml.
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Replacement Item This antibody may replace item sc-133448 from Santa Cruz Biotechnology.
Immunogen The immunogen is a synthetic peptide directed towards the C-terminal region of Human FBXW7
Purification Affinity Purified
Predicted Homology Based on Immunogen Sequence Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
Complete computational species homology data ARP47419_P050
Peptide Sequence Synthetic peptide located within the following region: LKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRNGTEETKLLVL
Concentration Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Blocking Peptide Catalog # AAP47419
Datasheets/Manuals Printable datasheet for ARP47419_P050
Sample Type Confirmation

FBXW7 is supported by BioGPS gene expression data to be expressed in Jurkat

Publications

Gong, Y. et al. Pan-cancer genetic analysis identifies PARK2 as a master regulator of G1/S cyclins. Nat. Genet. 46, 588-94 (2014). IHC, WB, Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish 24793136

Gene Symbol FBXW7
Official Gene Full Name F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
Alias Symbols AGO, CDC4, FBW6, FBW7, FBX30, FBXO30, FBXW6, SEL-10, SEL10, hAgo, hCdc4
NCBI Gene Id 55294
Protein Name F-box/WD repeat-containing protein 7
Description of Target FBXW7 is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in FBXW7 gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers.
Swissprot Id Q969H0-4
Protein Accession # NP_001013433
Nucleotide Accession # NM_001013415
Protein Size (# AA) 707
Molecular Weight 80kDa
Tissue Tool Find tissues and cell lines supported by DNA array analysis
RNA Seq Find tissues and cell lines supported by RNA-seq analysis
Protein Interactions MCL1; CDC34; CCNE1; FBXW7; CUL1; UBE2D1; PIN1; DAB2IP; YAP1; SKP1; MAP4K1; EYA1; KLF5; SREBF1; NOTCH1; UBE2QL1; Creb3l2; Creb3l1; SIC1; CSF3R; KLF2; NCOA3; PTEN; NFE2L1; HSP90AA1; MED11; MED19; MED8; MED30; MED10; MED28; MED29; MED9; MED15; MED31; MED4; M
  1. What is the species homology for "FBXW7 Antibody - C-terminal region (ARP47419_P050)"?

    The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish".

  2. How long will it take to receive "FBXW7 Antibody - C-terminal region (ARP47419_P050)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "FBXW7 Antibody - C-terminal region (ARP47419_P050)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "FBXW7 Antibody - C-terminal region (ARP47419_P050)"?

    This target may also be called "AGO, CDC4, FBW6, FBW7, FBX30, FBXO30, FBXW6, SEL-10, SEL10, hAgo, hCdc4" in publications.

  5. What is the shipping cost for "FBXW7 Antibody - C-terminal region (ARP47419_P050)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "FBXW7 Antibody - C-terminal region (ARP47419_P050)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "FBXW7 Antibody - C-terminal region (ARP47419_P050)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "80kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "FBXW7 Antibody - C-terminal region (ARP47419_P050)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data tab on the product page.

  10. What are positive controls for "FBXW7"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "FBXW7"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "FBXW7"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "FBXW7"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "FBXW7"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "FBXW7"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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