Catalog No: ARP47419_P050
Price: $0.00
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ARP47419_P050
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Datasheets/ManualsPrintable datasheet for ARP47419_P050
Product Info
Tested Species ReactivityHuman
Predicted Species ReactivityHuman, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ClonalityPolyclonal
HostRabbit
ApplicationIHC, WB
Additional InformationIHC Information: Paraffin embedded kidney tissue, tested with an antibody dilution of 2.5 ug/ml.
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThe immunogen is a synthetic peptide directed towards the C-terminal region of Human FBXW7
PurificationAffinity Purified
Predicted Homology Based on Immunogen SequenceCow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
Peptide SequenceSynthetic peptide located within the following region: LKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRNGTEETKLLVL
Concentration0.5 mg/ml
Blocking PeptideCatalog # AAP47419
Sample Type Confirmation

FBXW7 is supported by BioGPS gene expression data to be expressed in Jurkat

Enhanced Validation
WBY
SPR
YCHAROS
Publications

FBXW7 mediates high glucose‑induced SREBP‑1 expression in renal tubular cells of diabetic nephropathy under PI3K/Akt pathway regulation. Mol Med Rep. 23 (2021). 33537812

Gong, Y. et al. Pan-cancer genetic analysis identifies PARK2 as a master regulator of G1/S cyclins. Nat. Genet. 46, 588-94 (2014). 24793136

Gene SymbolFBXW7
Gene Full NameF-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
Alias SymbolsAGO, CDC4, FBW6, FBW7, hAgo, FBX30, FBXW6, SEL10, hCdc4, FBXO30, SEL-10
NCBI Gene Id55294
Protein NameF-box/WD repeat-containing protein 7
Description of TargetFBXW7 is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in FBXW7 gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers.
Uniprot IDQ969H0-4
Protein Accession #NP_001013433
Nucleotide Accession #NM_001013415
Protein Size (# AA)707
Molecular Weight80 kDa
Protein InteractionsMCL1; CDC34; CCNE1; FBXW7; CUL1; UBE2D1; PIN1; DAB2IP; YAP1; SKP1; MAP4K1; EYA1; KLF5; SREBF1; NOTCH1; UBE2QL1; Creb3l2; Creb3l1; SIC1; CSF3R; KLF2; NCOA3; PTEN; NFE2L1; HSP90AA1; MED11; MED19; MED8; MED30; MED10; MED28; MED29; MED9; MED15; MED31; MED4; M
  1. What is the species homology for "FBXW7 Antibody - C-terminal region (ARP47419_P050)"?

    The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish".

  2. How long will it take to receive "FBXW7 Antibody - C-terminal region (ARP47419_P050)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "FBXW7 Antibody - C-terminal region (ARP47419_P050)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "FBXW7 Antibody - C-terminal region (ARP47419_P050)"?

    This target may also be called "AGO, CDC4, FBW6, FBW7, hAgo, FBX30, FBXW6, SEL10, hCdc4, FBXO30, SEL-10" in publications.

  5. What is the shipping cost for "FBXW7 Antibody - C-terminal region (ARP47419_P050)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "FBXW7 Antibody - C-terminal region (ARP47419_P050)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "FBXW7 Antibody - C-terminal region (ARP47419_P050)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "80 kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "FBXW7 Antibody - C-terminal region (ARP47419_P050)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "FBXW7"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "FBXW7"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "FBXW7"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "FBXW7"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "FBXW7"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "FBXW7"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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