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FBXW2 Antibody - middle region (ARP43109_P050)

100 ul
$319.00
In Stock
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Conjugation Options

ARP43109_P050-FITC Conjugated

ARP43109_P050-HRP Conjugated

ARP43109_P050-Biotin Conjugated

Gene Symbol:
FBXW2
Official Gene Full Name:
F-box and WD repeat domain containing 2
NCBI Gene Id:
26190
Protein Name:
F-box/WD repeat-containing protein 2
Swissprot Id:
Q9UKT8
Protein Accession #:
NP_036296
Nucleotide Accession #:
NM_012164
Alias Symbols:
FBW2, Fwd2, MGC117371, Md6
Replacement Item:
This antibody may replace item sc-145142 from Santa Cruz Biotechnology.
Description of Target:
F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. FBXW2 is the second identified member of the F-box family and contains multiple WD-40 repeats.F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats.
Protein Size (# AA):
454
Molecular Weight:
51kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Affinity Purified
Application:
WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis
Immunogen:
The immunogen is a synthetic peptide directed towards the middle region of human FBXW2
Predicted Species Reactivity:
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
Tested Species Reactivity:
Human
Predicted Homology Based on Immunogen Sequence:
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 93%
Complete computational species homology data:
ARP43109_P050
Peptide Sequence:
Synthetic peptide located within the following region: SLISRWPLPEYRKSKRGSSFLAGEASWLNGLDGHNDTGLVFATSMPDHSI
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
SKP1; FBXO6; CUL1; GNB2L1; GCM1; HSP90AA1; BTG2; BTG1; REST; RBX1; FBXW8; EP300; UBE2D2; CDC34;
Blocking Peptide:
Catalog # AAP43109 (Previous Catalog # AAPP25080)
Datasheets/Manuals:
Printable datasheet for ARP43109_P050
Sample Type Confirmation:

FBXW2 is supported by BioGPS gene expression data to be expressed in Jurkat

Target Reference:
Yang,C.S., (2005) J. Biol. Chem. 280 (11), 10083-10090
Publications:

Van Rechem, C. et al. The SKP1-Cul1-F-box and leucine-rich repeat protein 4 (SCF-FbxL4) ubiquitin ligase regulates lysine demethylase 4A (KDM4A)/Jumonji domain-containing 2A (JMJD2A) protein. J. Biol. Chem. 286, 30462-70 (2011). WB, Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish 21757720

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