fbpA Antibody (OACA02281)

Catalog No: OACA02281

Size:100ug

Product Info

• Predicted Species Reactivity: Mycobacterium tuberculosis
• Product Format: Liquid
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Western blot
• Reconstitution and Storage: -20°C or -80°C
• Immunogen: Recombinant Mycobacterium tuberculosis Diacylglycerol acyltransferase/mycolyltransferase Ag85A protein (53-331AA)
• Purification: Protein G Purified
• Reference: [1] Cloning, sequence determination, and expression of a 32-kilodalton-protein gene of Mycobacterium tuberculosis.'Borremans M., de Wit L., Volckaert G., Ooms J., de Bruyn J., Huygen K., van Vooren J.P., Stelandre M., Verhofstadt R., Content J.Infect. Immun. 57:3123-3130(1989)
  [2] Novel insights into the genetics, biochemistry, and immunocytochemistry of the 30-kilodalton major extracellular protein of Mycobacterium tuberculosis.'Harth G., Lee B.Y., Wang J., Clemens D.L., Horwitz M.A.Infect. Immun. 64:3038-3047(1996)
  [3] Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.'Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G.Nature 393:537-544(1998)

Target Info

• Gene Symbol: fbpA
• Gene Full Name: diacylglycerol acyltransferase/mycolyltransferase Ag85A
• Alias Symbols: 85A;Acyl-CoA:diacylglycerol acyltransferase;Antigen 85 complex A;diacylglycerol acyltransferase/mycolyltransferase Ag85A;Fibronectin-binding protein A;mpt44;Rv3804c.
• NCBI Gene Id: 886132
• Protein Name: Diacylglycerol acyltransferase/mycolyltransferase Ag85A
• Description of Target: The antigen 85 proteins (FbpA, FbpB, FbpC) are responsible for the high affinity of mycobacteria for fibronectin, a large adhesive glycoprotein, which facilitates the attachment of M.tuberculosis to murine alveolar macrophages (AMs). They also help to maintain the integrity of the cell wall by catalyzing the transfer of mycolic acids to cell wall arabinogalactan, and through the synthesis of alpha,alpha-trehalose dimycolate (TDM, cord factor). They catalyze the transfer of a mycoloyl residue from one molecule of alpha,alpha-trehalose monomycolate (TMM) to another TMM, leading to the formation of TDM. FbpA mediates triacylglycerol (TAG) formation with long-chain acyl-CoA as the acyl donor and 1,2-dipalmitoyl-sn-glycerol (1,2-dipalmitin) as the acyl acceptor. It has a preference for C26:0-CoA over C18:1-CoA.
• Uniprot ID: P9WQP3
• Protein Accession #: WP_003900759.1; YP_979945.1
• Nucleotide Accession #: NC_008769.1