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Catalog No: ARP40366_T100-FITC
Size:100ul
Price: $384.00
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ARP40366_T100-FITC
Availability: Domestic: within 1-2 days delivery | International: 1-2 days
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FBL Antibody - N-terminal region : FITC (ARP40366_T100-FITC)

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Datasheets/ManualsPrintable datasheet for anti-FBL (ARP40366_T100-FITC) antibody
Product Info
Predicted Species ReactivityHuman, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer.
ClonalityPolyclonal
HostRabbit
ConjugationFITC: Fluorescein Isothiocyanate
ApplicationIHC, WB
Reconstitution and StorageAll conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
ImmunogenThe immunogen is a synthetic peptide directed towards the N terminal region of human FBL
Predicted Homology Based on Immunogen SequenceCow: 86%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%
Peptide SequenceSynthetic peptide located within the following region: GGGFHSGGNRGRGRGGKRGNQSGKNVMVEPHRHEGVFICRGKEDALVTKN
Concentration0.5 mg/ml
Blocking PeptideFor anti-FBL (ARP40366_T100-FITC) antibody is Catalog # AAP40366 (Previous Catalog # AAPP22110)
Sample Type Confirmation

FBL is supported by BioGPS gene expression data to be expressed in Jurkat

ReferenceBouwmeester,T., (2004) Nat. Cell Biol. 6 (2), 97-105
Publications

Ernoult-Lange, M. et al. Nucleocytoplasmic traffic of CPEB1 and accumulation in Crm1 nucleolar bodies. Mol. Biol. Cell 20, 176-87 (2009). ICC/IF, Human, Rat, Dog, Horse, Guinea pig, Mouse, Rabbit, Bovine 18923137

Armistead, J. et al. Mutation of a gene essential for ribosome biogenesis, EMG1, causes Bowen-Conradi syndrome. Am. J. Hum. Genet. 84, 728-39 (2009). WB, Human, Rat, Dog, Horse, Guinea pig, Mouse, Rabbit, Bovine 19463982

Gene SymbolFBL
Gene Full NameFibrillarin
Alias SymbolsFIB, FLRN, Nop1, RNU3IP1
NCBI Gene Id2091
Protein NamerRNA 2'-O-methyltransferase fibrillarin
Description of TargetFBL is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. FBL contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin.This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin.
Uniprot IDP22087
Protein Accession #NP_001427
Nucleotide Accession #NM_001436
Protein Size (# AA)321
Molecular Weight35kDa
Protein InteractionsUBC; CEP250; TP53; SUMO2; SUMO3; LIN28A; LIN28B; RPA3; RPA2; RPA1; ERG; RNF2; BMI1; SUZ12; EED; EZH2; TARDBP; UBD; NCL; ARFGEF1; PAN2; CBX8; ITGA4; FN1; VCAM1; MAGOH; EIF4A3; EEF1A1; DHX15; NSUN2; NOP58; MRTO4; GNL3; RSL1D1; SRRM2; BOP1; RRS1; EBNA1BP2; P
  1. What is the species homology for "FBL Antibody - N-terminal region : FITC (ARP40366_T100-FITC)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit".

  2. How long will it take to receive "FBL Antibody - N-terminal region : FITC (ARP40366_T100-FITC)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "FBL Antibody - N-terminal region : FITC (ARP40366_T100-FITC)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "FBL Antibody - N-terminal region : FITC (ARP40366_T100-FITC)"?

    This target may also be called "FIB, FLRN, Nop1, RNU3IP1" in publications.

  5. What is the shipping cost for "FBL Antibody - N-terminal region : FITC (ARP40366_T100-FITC)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "FBL Antibody - N-terminal region : FITC (ARP40366_T100-FITC)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "FBL Antibody - N-terminal region : FITC (ARP40366_T100-FITC)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "35kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "FBL Antibody - N-terminal region : FITC (ARP40366_T100-FITC)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "FBL"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "FBL"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "FBL"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "FBL"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "FBL"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "FBL"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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