FASLG Antibody (OATA00284)

Catalog No: OATA00284

Size:100 ug

Product Info

• Tested Species Reactivity: Human
• Product Format: Liquid. 10 mM NaH2PO4, 150 mM NaCl, pH7.2
• Clonality: Monoclonal
• Clone: NOK-1
• Isotype: Mouse IgG1, kappa
• Host: Mouse
• Application: FC, FN
• Reconstitution and Storage: 2-8C
• Specificity: CD178 (Fas ligand)
• Application Info: This purified format is guaranteed to be >90% pure as determined by SDS-PAGE analysis. Citations are provided as a convenience to you - please consult Materials and Methods sections for additional details about the use of any product in these publications.
• Reference:

  Tanaka M, Suda T, Takahashi T, and Nagata S. 1995. EMBO J. 14(6):1129-1135.

  Kayagaki N, Kawasaki A, Ebata T, Ohmoto H, Ikeda S, Inoue S, Yoshino K, Okumura K, and Yagita H. 1995. J Exp Med. 182(6):1777-1783.

  Suda T, Hashimoto H, Tanaka M, Ochi T, Nagata S. 1997. J Exp Med. 186(12):2045-2050.

  Ehrenschwender M, Wajant H. 2009. Adv Exp Med Biol. 647:64-93.

Target Info

• Gene Symbol: FASLG
• Gene Full Name: Fas ligand
• Alias Symbols: APTL, FASL, CD178, CD95L, ALPS1B, CD95-L, TNFSF6, TNLG1A, APT1LG1
• NCBI Gene Id: 356
• Protein Name: tumor necrosis factor ligand superfamily member 6
• Description of Target: This gene is a member of the tumor necrosis factor superfamily. The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death. It has also been implicated in the progression of several cancers. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). Alternatively spliced transcript variants have been described.
• Uniprot ID: P48023
• Protein Accession #: NP_000630.1
• Nucleotide Accession #: NM_000639.2