FAIM2 Antibody (OAPB00110)

Catalog No: OAPB00110

Size:100UG

Western blot analysis of LFG in EL4 cell lysate with LFG antibody at (A) 0.5 and (B) 1 ug/mL.

Immunohistochemistry of LFG in mouse brain tissue with LFG antibody at 5 ug/mL.

Product Info

• Predicted Species Reactivity: Bovine|Human|Mouse|Rat
• Product Format: Liquid. FAIM2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Clonality: Polyclonal
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Immunohistochemistry-Paraffin|Western blot
  Buffer: Antibody is supplied in PBS containing 0.02% sodium azide.
• Reconstitution and Storage: LFG antibody can be stored at 4C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Immunogen: FAIM2 antibody was raised against a 16 amino acid synthetic peptide from near the amino terminus of human FAIM2. The immunogen is located within the first 50 amino acids of FAIM2.
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Human; Mouse; Rat
• Concentration: 1 mg/ml
• Blocking Peptide: For anti-FAIM2 (OAPB00110) antibody is Catalog # OEPB02580
• Application Info: LFG antibody can be used for detection of LFG by Western blot at 0.5 - 1 ug/ml. (Optimal dilution should be determined by user)
• Reference: Lockshin RA, Osborne B, and Zakeri Z. Cell death in the third millennium. Cell Death Differ. 2000; 7:2-7.;Somia NV, Schmitt MJ, Vetter DE, et al. LFG: an anti-apoptotic gene that provides protection from Fas-mediated cell death. Proc. Natl. Acad. Sci. USA 1999; 96:12667-72.;Schneider TJ, Fischer GM, Donohoe TJ, et al. A novel gene coding for a Fas apoptosis inhibitory molecule (FAIM) isolated from inducibly Fas-resistant B lymphocytes. J. Exp. Med. 1999; 189:949-55.;Schweitzer B, Taylor V, Welcher AA, et al. Neural membrane protein 35 (NMP35): a novel member of a gene family which is highly expressed in the adult nervous system. Mol. Cell. Neurosci. 1998; 11:260-73.

Target Info

• Gene Symbol: FAIM2
• Gene Full Name: Fas apoptotic inhibitory molecule 2
• Alias Symbols: Fas apoptotic inhibitory molecule 2;LFG;LFG2;neural membrane protein 35;NGP35;NMP35;protein lifeguard 2;TMBIM2;transmembrane BAX inhibitor motif-containing protein 2.
• NCBI Gene Id: 23017
• Protein Name: lifeguard [Homo sapiens]|Protein lifeguard 2
• Description of Target: Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development.
• Uniprot ID: Q9BWQ8
• Protein Accession #: https://www.ncbi.nlm.nih.gov/protein/AAF06327
• Nucleotide Accession #: NM_012306.3