FADD Antibody (Phospho-Ser194) (OASG02626)

Catalog No: OASG02626

Size:100 uL

Western Blot using Mouse Kidney, Mouse Brain, Mouse Spleen, Mouse Lung

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid. 1 mg/mL in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: WB, IHC
• Reconstitution and Storage: Store at -20C. Avoid repeated freeze/thaw cycles.
• Immunogen: Synthesized peptide derived from human FADD around the phosphorylation site of S194. Location: 130-210aa.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Concentration: 1 mg/ml
• Target Post-Translational Modification: Phospho-Ser194
• Specificity: Phospho-FADD (S194) Polyclonal Antibody detects endogenous levels of FADD protein only when phosphorylated at S194.
• Application Info: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;

Target Info

• Gene Symbol: FADD
• Gene Full Name: Fas (TNFRSF6)-associated via death domain
• Alias Symbols: GIG3, MORT1
• NCBI Gene Id: 8772;
• Description of Target: The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.
• Uniprot ID: Q13158
• Molecular Weight: 28 kDa