FADD Antibody (Phospho-Ser191) (OASG02627)

Catalog No: OASG02627

Size:100 uL

Western Blot using JK-1

Product Info

• Predicted Species Reactivity: Mouse
• Product Format: Liquid PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: WB, IHC
  Tissue Specificity: Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes.
  Sequence & Domain Family: Contains a death domain involved in the binding of the corresponding domain within Fas receptor. The interaction between the FAS and FADD death domains is crucial for the formation of the death-inducing signaling complex (DISC).
• Reconstitution and Storage: Store at -20C. Avoid repeated freeze/thaw cycles.
• Immunogen: Synthesized peptide derived from human FADD around the phosphorylation site of S194. Location: 130-210aa.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Concentration: 1 mg/ml
• Target Post-Translational Modification: Phospho-Ser191
• Specificity: Phospho-FADD (S191) Polyclonal Antibody detects endogenous levels of FADD protein only when phosphorylated at S191.
• Application Info: WB: 1:500~2000
  IHC: 1:100~300
  ELISA: 1:10000

Target Info

• Gene Symbol: FADD
• Gene Full Name: Fas (TNFRSF6)-associated via death domain
• Alias Symbols: GIG3, MORT1
• NCBI Gene Id: 8772;
• Description of Target: Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.
• Uniprot ID: Q13158
• Molecular Weight: 25 kDa