FABP4 Protein (OPPA02096)

Catalog No: OPPA02096 (Formerly GWB-E83D1A)

Size:5ug

Product Info

• Product Format: FABP4 His-Tag is supplied in 20mM Tris HCL pH=8, 0.5mM DTT and 50% glycerol. Physical appearance: Sterile Filtered colorless liquid formulation.
• Host: E. Coli
  Product Introduction: Adipocyte fatty acid binding protein FABP4 is a 15 kDa member of the intracellular fatty acid binding protein (FABP) family, which is known for the ability to bind fatty acids and related compounds (bile acids or retinoids) in an internal cavity. FABP4 is expressed in a differentiation-dependent fashion in adipocytes and is a critical gene in the regulation of the biological function of these cells.In mice, targeted mutations in FABP4 provide significant protection from hyperinsulinemia and insulin resistance in the context of both dietary and genetic obesity. Adipocytes obtained from FABP4-deficient mice also have reduced efficiency of ipolysis in vitro and in vivo, and these mice exhibited moderately improved systemic dyslipidemia. Recent studies also demonstrated FABP4 expression in macrophages upon differentiation and activation. In these cells, FABP4 modulates inflammatory responses and cholesterol ester accumulation, and total or macrophage-specific FABP4 deficiency confers dramatic protection against atherosclerosis in the apoE-/- mice. These results indicate a central role for FABP4 in the development of major components of the metabolic syndrome through its distinct actions in adipocytes and macrophages.
  Product Description: FABP4 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 132 amino acids and having a molecular mass of 18 kDa. FABP4 is fused to His tag at N-terminus and purified by standard chromatography techniques.
• Reconstitution and Storage: Store at 4C if entire vial will be used within 2-4 weeks. Store, frozen at -20C for longer periods of time. Please avoid freeze thaw cycles.
• Purity: Greater than 95% as determined by SDS-PAGE.

Target Info

• Gene Symbol: FABP4 His
• Alias Symbols: aP2, ALBP, AFABP, A-FABP, HEL-S-104
• NCBI Gene Id: 2167
• Protein Name: Fatty acid-binding protein, adipocyte
• Description of Target: Recombinant Human Fatty Acid Binding Protein-4, His Tag
• Uniprot ID: P15090
• Protein Accession #: NP_001433.1