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F10 Antibody (OAGA00797)

Catalog#: OAGA00797
Domestic: within 1 week delivery International: 1 week
More Information
Predicted Species Reactivity Human
Product Format Liquid
Clonality Polyclonal
Isotype IgG
Host Rabbit
Application ICC, IF, IHC-FFPE, WB
Additional Information Background: This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity. [provided by RefSeq]
:: Positive Controls: human F10-transfected 293T cells
:: Cellular Localization: Secreted
Reconstitution and Storage Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
Replacement Item This antibody may replace item sc-69654 from Santa Cruz Biotechnology.
Immunogen Recombinant fragment corresponding to a region within amino acids 33 and 312 of Factor X (Uniprot ID#P00742)
Purification Purified by antigen-affinity chromatography.
Concentration 1 mg/ml
Datasheets/Manuals Printable datasheet for anti-F10 antibody - OAGA00797
Application Info Suggested starting dilutions are as follows: WB: 1:500-1:3000, IHC-P: 1:100-1:1000 [suggested antigen retrieval using heat mediated 10mM Citrate buffer (pH6.0) or Tris-EDTA buffer (pH8.0)], ICC/IF: 1:100-1:1000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.
Storage Buffer 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Gene Symbol F10
Official Gene Full Name Coagulation factor X
Alias Symbols FX antibody, FXA antibody, F10 antibody, Stuart-Prower factor antibody, prothrombinase antibody, coagulation factor X antibody, factor Xa antibody
NCBI Gene Id 2159
Protein Name Coagulation factor X
Swissprot Id P00742
Protein Accession # NP_000495.1
Molecular Weight 55 kDa
Tissue Tool Find tissues and cell lines supported by DNA array analysis to express F10.
RNA Seq Find tissues and cell lines supported by RNA-seq analysis to express F10.
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