F Antibody (OABF00317)

Catalog No: OABF00317

Size:100UL

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L1 mouse brain lysates L2 mouse heart lysates probed with Anti Measles Virus Fusion Protein Polyclonal Antibody, Unconjugated (OABF00317) at 1:200 overnight at 4C. Followed by conjugation to secondary antibody at 1:3000 for 90 min at 37C. Predicted band 55kD. Observed band size:55kD.

Product Info

• Predicted Species Reactivity: Measles Virus|Virus
• Product Format: Liquid. Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay
• Additional Information: Subcellular location: Cytoplasm
• Reconstitution and Storage: -20°C
• Immunogen: KLH conjugated synthetic peptide derived from Measles virus fusion protein
• Purification: Protein A Purified
• Concentration: 1 ug/ul
• Application Info: WB: 1:100 - 1000
  IHC-P: : 1:100 - 500

Target Info

• Gene Symbol: F
• Gene Full Name: fusion protein
• Alias Symbols: fusion protein;MeVgp4.
• NCBI Gene Id: 1489800
• Protein Name: Fusion glycoprotein F0
• Description of Target: Class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and plasma cell membrane fusion, the heptad repeat (HR) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and plasma cell membranes. Directs fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm. This fusion is pH independent and occurs directly at the outer cell membrane. The trimer of F1-F2 (F protein) probably interacts with H at the virion surface. Upon HN binding to its cellular receptor, the hydrophobic fusion peptide is unmasked and interacts with the cellular membrane, inducing the fusion between cell and virion membranes. Later in infection, F proteins expressed at the plasma membrane of infected cells could mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis (By similarity).
• Uniprot ID: P69353