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EXT1 Antibody - middle region (OAAB12248)

Catalog#: OAAB12248
Domestic: within 1 week delivery International: 1 week
More Information
Predicted Species ReactivityCow, Human, Mouse
Product FormatPurified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Additional InformationPrecautions: EXT1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
::Function: Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone Appears to be a tumor suppressor
::Cellular Location: Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Note=The EXT1/EXT2 complex is localized in the Golgi apparatus
Tissue Location: Ubiquitous.
Reconstitution and StorageMaintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Replacement ItemThis antibody may replace item sc-106792 from Santa Cruz Biotechnology.
ImmunogenThis EXT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 298-326 amino acids from the Central region of human EXT1.
Predicted Homology Based on Immunogen SequenceCow; Human; Mouse
ConcentrationApproximately 0.5mg/ml. Actual concentration varies with each lot.
Datasheets/ManualsPrintable datasheet for OAAB12248
Sample Type Confirmation

EXT1 is supported by BioGPS gene expression data to be expressed in K562

Application InfoWB: 1:1000

de Andrea, C. E. et al. Secondary peripheral chondrosarcoma evolving from osteochondroma as a result of outgrowth of cells with functional EXT. Oncogene 31, 1095-104 (2012). WB, Cow, Human, Mouse 21804604

Gene SymbolEXT1
Alias SymbolsEXT1, Exostosin-1, Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase, Multiple exostoses protein 1, Putative tumor suppressor protein EXT1
NCBI Gene Id2131
Protein NameExostosin-1
Description of TargetPeptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Swissprot IdQ16394
Protein Accession #NP_000118.2
Molecular Weight86255 Da
Tissue ToolFind tissues and cell lines supported by DNA array analysis to express EXT1.
RNA SeqFind tissues and cell lines supported by RNA-seq analysis to express EXT1.
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