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EXT1 Antibody - middle region (OAAB12248)

400ul
$390.00
In Stock
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Predicted Species Reactivity:
Cow, Human, Mouse
Product Format:
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Ig
Host:
Rabbit
Application:
WB
Additional Information:
Precautions: EXT1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
:::
Function: Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone Appears to be a tumor suppressor
:::
Cellular Location: Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Note=The EXT1/EXT2 complex is localized in the Golgi apparatus
Tissue Location: Ubiquitous.
Reconstitution and Storage:
Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Gene Symbol:
EXT1
NCBI Gene Id:
2131
Protein Name:
Exostosin-1
Swissprot Id:
Q16394
Protein Accession #:
NP_000118.2
Alias Symbols:
EXT1, Exostosin-1, Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase, Multiple exostoses protein 1, Putative tumor suppressor protein EXT1
Replacement Item:
This antibody may replace item sc-106792 from Santa Cruz Biotechnology.
Description of Target:
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Molecular Weight:
86255 Da
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express EXT1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express EXT1.
Immunogen:
This EXT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 298-326 amino acids from the Central region of human EXT1.
Predicted Homology Based on Immunogen Sequence:
Cow; Human; Mouse
Concentration:
Approximately 0.5mg/ml. Actual concentration varies with each lot.
Datasheets/Manuals:
Printable datasheet for OAAB12248
Sample Type Confirmation:

EXT1 is supported by BioGPS gene expression data to be expressed in K562

Application Info:
WB: 1:1000
Publications:

de Andrea, C. E. et al. Secondary peripheral chondrosarcoma evolving from osteochondroma as a result of outgrowth of cells with functional EXT. Oncogene 31, 1095-104 (2012). WB, Cow, Human, Mouse 21804604

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