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Catalog No: ARP41086_P050
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ARP41086_P050
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Datasheets/ManualsPrintable datasheet for anti-EXOSC6 (ARP41086_P050) antibody
Product Info
Tested Species ReactivityHuman
Predicted Species ReactivityHuman, Mouse, Rat, Cow, Pig, Zebrafish
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ClonalityPolyclonal
HostRabbit
ApplicationWB
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThe immunogen is a synthetic peptide directed towards the N terminal region of human EXOSC6
PurificationAffinity Purified
Predicted Homology Based on Immunogen SequenceCow: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rat: 100%; Zebrafish: 86%
Peptide SequenceSynthetic peptide located within the following region: LYAADEEEAPGTRDPTRLRPVYARAGLLSQAKGSAYLEAGGTKVLCAVSG
Concentration0.5 mg/ml
Blocking PeptideFor anti-EXOSC6 (ARP41086_P050) antibody is Catalog # AAP41086 (Previous Catalog # AAPP22422)
ReferenceRaijmakers,R., (2002) J. Mol. Biol. 323 (4), 653-663
Gene SymbolEXOSC6
Gene Full NameExosome component 6
Alias Symbolsp11, EAP4, MTR3, Mtr3p, hMtr3p
NCBI Gene Id118460
Protein NameExosome complex component MTR3
Description of TargetEXOSC6 constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation.This gene product constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation.
Uniprot IDQ5RKV6
Protein Accession #NP_478126
Nucleotide Accession #NM_058219
Protein Size (# AA)272
Molecular Weight30kDa
Protein InteractionsCEP250; DCP1B; EXOSC6; CHPF; MIF4GD; XRN1; NDUFA13; MRPL4; EXOSC1; MRPS18B; UPF2; RAB3GAP2; SKIV2L2; GSE1; EXOSC7; EXOSC8; ZFP36; TUFM; EXOSC10; MAN2C1; ESRRA; C1QBP; AICDA; DIS3L; EXOSC4; EXOSC3; CUL3; ELAVL1; HDGF; UBC; EXOSC5; DNAJC30; MOCS3; MPP6; EXO
  1. What is the species homology for "EXOSC6 Antibody - N-terminal region (ARP41086_P050)"?

    The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human, Mouse, Rat, Cow, Pig, Zebrafish".

  2. How long will it take to receive "EXOSC6 Antibody - N-terminal region (ARP41086_P050)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "EXOSC6 Antibody - N-terminal region (ARP41086_P050)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "EXOSC6 Antibody - N-terminal region (ARP41086_P050)"?

    This target may also be called "p11, EAP4, MTR3, Mtr3p, hMtr3p" in publications.

  5. What is the shipping cost for "EXOSC6 Antibody - N-terminal region (ARP41086_P050)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "EXOSC6 Antibody - N-terminal region (ARP41086_P050)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "EXOSC6 Antibody - N-terminal region (ARP41086_P050)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "30kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "EXOSC6 Antibody - N-terminal region (ARP41086_P050)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "EXOSC6"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "EXOSC6"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "EXOSC6"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "EXOSC6"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "EXOSC6"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "EXOSC6"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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