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Catalog No: OACA06208
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OACA06208
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  • $55: Antibody & Protein in US
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Datasheets/ManualsPrintable datasheet for EXOSC5 Antibody (OACA06208) (OACA06208)
Product Info
Predicted Species ReactivityHuman
Product FormatLiquid
ClonalityPolyclonal
IsotypeIgG
HostRabbit
ConjugationUnconjugated
ApplicationEnzyme-linked immunosorbent assay|Immunohistochemistry|Western blot
Reconstitution and Storage-20°C or -80°C
ImmunogenRecombinant Human Exosome complex component RRP46 protein (1-235AA)
PurificationProtein G Purified
Preservative0.03% Proclin 300
Formulation50% Glycerol, 0.01M PBS, PH 7.4
Gene SymbolEXOSC5
Gene Full Nameexosome component 5
Alias Symbolschronic myelogenous leukemia tumor antigen 28;exosome complex component RRP46;exosome complex exonuclease RRP46;Exosome component 5;exosome component Rrp46;hRrp46p;p12B;ribosomal RNA-processing protein 46;RRP41B;RRP46;Rrp46p.
NCBI Gene Id56915
Protein NameExosome complex component RRP46
Description of TargetNon-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.
Uniprot IDQ9NQT4
Protein Accession #NP_064543
Nucleotide Accession #NM_020158
  1. What is the species homology for "EXOSC5 Antibody (OACA06208)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".

  2. How long will it take to receive "EXOSC5 Antibody (OACA06208)"?

    This item is available "Domestic: Antibody & Kits: 2 weeks | Proteins: 4-6 weeks | International: Antibody & Kits: 2 weeks | Proteins: 4-6 weeks".

  3. What buffer format is "EXOSC5 Antibody (OACA06208)" provided in?

    This item is provided in "Liquid".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "EXOSC5 Antibody (OACA06208)"?

    This target may also be called "chronic myelogenous leukemia tumor antigen 28;exosome complex component RRP46;exosome complex exonuclease RRP46;Exosome component 5;exosome component Rrp46;hRrp46p;p12B;ribosomal RNA-processing protein 46;RRP41B;RRP46;Rrp46p." in publications.

  5. What is the shipping cost for "EXOSC5 Antibody (OACA06208)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "EXOSC5 Antibody (OACA06208)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "EXOSC5 Antibody (OACA06208)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "EXOSC5 Antibody (OACA06208)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "EXOSC5"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "EXOSC5"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "EXOSC5"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "EXOSC5"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "EXOSC5"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "EXOSC5"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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