Catalog No: OPPA01354 (Formerly GWB-961C23)
Size:5UG
Price: $75.00
SKU
OPPA01354
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EXOSC10 Protein (OPPA01354)

Datasheets/ManualsPrintable datasheet for OPPA01354
Product Info
Predicted Species ReactivityHuman
Product FormatPM/Scl 100is supplied at a concentration of 0.8mg/ml in 20mM HEPES, pH-7.5, 100mM NaCl, 0.01mM EDTA, 0.02% SDS. Physical appearance: Sterile Filtered clear solution.
HostSf9 Insect Cells
ApplicationWB
::Immunological Functions: 1. Binds IgG-type human auto-antibodies.2. Standard ELISA test (checker-board analysis of positive/negative sera panels).
::Product Introduction: PM/Scl 100 is a nucleolar protein and represents one crucial component of the so-called "PM/Scl complex" or "nuclear exosome", which is an RNA-processing complex consisting of a number of exoribonucleases (not to be confused with certain multivesicular bodies which are shed by cultured cells into the culture fluid and are also called exosomes).Autoantibodies against PM/Scl 100 occur in patients suffering from polymyositis, scleroderma or polymyositis/scleroderma overlap syndromes. While antibodies to other components of the exosome complex (PM/Scl 75, several Rrp proteins) can be found in some sera, practically all patients with autoantibodies against the PM/Scl complex are positive for PM/Scl 100 antibodies, making this specificity an important marker. The presence of PM/Scl 100 autoantibodies is a comparatively "good" prognostic sign in polymyositis/scleroderma overlap syndrome unlike the poor prognosis seen when other myositis and systemic sclerosis specific autoantibodies are present.
Product Description: PM/Scl 100 Human Recombinant produced in SF9 is a glycosylated, polypeptide chain having a molecular mass of 120 kDa. PM/Scl 100 is expressed with a -6xHis tag and purified by proprietary chromatographic techniques.
Reconstitution and StorageStore at 4C if entire vial will be used within 2-4 weeks. Store, frozen at -20C for longer periods of time. Avoid multiple freeze-thaw cycles.
PurityGreater than 70% as determined by SDS-PAGE.
Application InfoWestern-Blot with monoclonal anti-hexa-His-tag antibody & polymyositis patient sera.
Gene SymbolPM/Scl 100
Alias Symbolsp2, p3, p4, RRP6, PMSCL, Rrp6p, PM-Scl, PMSCL2, PM/Scl-100
NCBI Gene Id5394
Protein NameExosome component 10
Description of TargetRecombinant Human PM/Scl 100
Uniprot IDQ01780
Protein Accession #NP_001001998.1
Protein Size (# AA)Recombinant
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