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Catalog No: OPCD00592
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SKU
OPCD00592
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Datasheets/ManualsPrintable datasheet for EXO1 Recombinant Protein (OPCD00592)
Product Info
Predicted Species ReactivityHomo sapiens|Human
Product FormatFreeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
HostE.coli
ConjugationUnconjugated
ApplicationCtrl (+), SDS-PAGE, WB
Additional InformationEndotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
Residues: Met1-Ile250
Isoelectric Point: 9.2
Subcellular Location: Nucleus
Reconstitution and Storage2°C to 8°C|-80°C
Concentration200 ug/mL (prior to lyoph)
Purity> 95%
SourceE.coli
TagN-terminal His Tag
Gene SymbolEXO1
Gene Full Nameexonuclease 1
Alias Symbolsexonuclease 1;Exonuclease I;HEX1;hExoI;rad2 nuclease family member, homolog of S. cerevisiae exonuclease 1.
NCBI Gene Id9156
Protein NameExonuclease 1
Description of Target5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis.
Uniprot IDQ9UQ84
Protein Accession #NP_003677.4
Nucleotide Accession #NM_003686.4
Protein Size (# AA)Met1~Ile250
Molecular Weight32kDa
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