ESRRB Antibody - C-terminal (OAPB01574)

Catalog No: OAPB01574

Size:100UG

Western blot analysis of ESRRB in human heart tissue lysate with ESRRB antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.

Product Info

• Predicted Species Reactivity: Human|Mouse|Rat
• Product Format: Liquid. ESRRB Antibody is supplied in PBS containing 0.02% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry-Paraffin|Western blot
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: ESRRB antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human ESRRB. The immunogen is located within amino acids 360 - 410 of ESRRB.
• Purification: Affinity Purified
• Concentration: 1 mg/ml

Target Info

• Gene Symbol: ESRRB
• Gene Full Name: estrogen related receptor beta
• Alias Symbols: DFNB35;ERR beta-2;ERR2;ERRb;ERRbeta2;ESRL2;estrogen receptor-like 2;estrogen-related nuclear receptor beta;Estrogen-related receptor beta;NR3B2;nuclear receptor ERRB2;nuclear receptor subfamily 3 group B member 2;orphan nuclear receptor;steroid hormone receptor ERR2.
• NCBI Gene Id: 2103
• Protein Name: Steroid hormone receptor ERR2|steroid hormone receptor ERR2 [Homo sapiens]
• Description of Target: Isoform 3: Transcription factor that binds a canonical ESRRB recognition (ERRE) sequence 5'TCAAGGTCA-3' localized on promoter and enhancer of targets genes regulating their expression or their transcription activity (PubMed:17920186, PubMed:19755138). Plays a role, in a LIF-independent manner, in maintainance of self-renewal and pluripotency of embryonic and trophoblast stem cells through different signaling pathways including FGF signaling pathway and Wnt signaling pathways. Upon FGF signaling pathway activation, interacts with KDM1A by directly binding to enhancer site of ELF5 and EOMES and activating their transcription leading to self-renewal of trophoblast stem cells. Also regulates expression of multiple rod-specific genes and is required for survival of this cell type (By similarity). Plays a role as transcription factor activator of GATA6, NR0B1, POU5F1 and PERM1 (PubMed:23836911). Plays a role as transcription factor repressor of NFE2L2 transcriptional activity and ESR1 transcriptional activity (PubMed:17920186, PubMed:19755138). During mitosis remains bound to a subset of interphase target genes, including pluripotency regulators, through the canonical ESRRB recognition (ERRE) sequence, leading to their transcriptional activation in early G1 phase. Can coassemble on structured DNA elements with other transcription factors like SOX2, POU5F1, KDM1A and NCOA3 to trigger ESRRB-dependent gene activation. This mechanism, in the case of SOX2 corecruitment prevents the embryonic stem cells (ESCs) to epiblast stem cells (EpiSC) transition through positive regulation of NR0B1 that inhibits the EpiSC transcriptional program. Also plays a role inner ear development by controlling expression of ion channels and transporters and in early placentation (By similarity).
• Uniprot ID: O95718
• Protein Accession #: https://www.ncbi.nlm.nih.gov/protein/NP_004443
• Nucleotide Accession #: NM_004452.3