ESR2 Antibody (OAAB07117)

Catalog No: OAAB07117

Size:400ul

ESR2 Antibody(Cat. #OAAB07117) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the ESR2 antibody detected the ESR2 protein (arrow).

ESR2 is strongly supported by BioGPS gene expression data to be expressed in K562

Product Info

• Predicted Species Reactivity: Human
• Product Format: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
• Clonality: Monoclonal
• Clone: 555CT18.5.5
• Isotype: IgG1
• Host: Mouse
• Application: WB
• Additional Information: Precautions: ESR2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
  Function: Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA- binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual
  Cellular Location: Nucleus.
  Tissue Location: Isoform beta-1 is expressed in testis and ovary, and at a lower level in heart, brain, placenta, liver, skeletal muscle, spleen, thymus, prostate, colon, bone marrow, mammary gland and uterus. Also found in uterine bone, breast, and ovarian tumor cell lines, but not in colon and liver tumors Isoform beta-2 is expressed in spleen, thymus, testis and ovary and at a lower level in skeletal muscle, pr
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: This ESR2 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 369-397 amino acids from human ESR2.
• Predicted Homology Based on Immunogen Sequence: Human
• Concentration: Approximately 0.5mg/ml. Actual concentration varies with each lot.
• Sample Type Confirmation:

  ESR2 is strongly supported by BioGPS gene expression data to be expressed in K562

• Application Info: WB: 1:100~500

Target Info

• Gene Symbol: ESR2
• Alias Symbols: Erb, ESRB, ODG8, ESTRB, NR3A2, ER-BETA, ESR-BETA
• NCBI Gene Id: 2100
• Protein Name: Estrogen receptor beta
• Description of Target: Mouse Monoclonal Antibody (Mab)
• Uniprot ID: Q92731
• Protein Accession #: NP_001035365.1
• Molecular Weight: 59216 Da