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| Datasheets/Manuals | Printable datasheet for OAAB16895 |
|---|
| Predicted Species Reactivity | Human |
|---|---|
| Product Format | Liquid PBS with 0.09% (W/V) sodium azide. |
| Clonality | Polyclonal |
| Isotype | Ig |
| Host | Rabbit |
| Application | WB |
| :: | Cellular Location: Endoplasmic reticulum membrane; Single-pass type I membrane protein |
| Reconstitution and Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Immunogen | This ERN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 781-810 amino acids from the C-terminal region of human ERN2. |
| Purification | This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Predicted Homology Based on Immunogen Sequence | Human |
| Concentration | Varies by lot. See vial for concentration. |
| Application Info | WB: 1:1000 |
| Gene Symbol | ERN2 |
|---|---|
| Alias Symbols | IRE1b, IRE2p, hIRE2p, IRE1-BETA |
| NCBI Gene Id | 10595 |
| Protein Name | Serine/threonine-protein kinase/endoribonuclease IRE2 |
| Description of Target | ERN2 induces translational repression through 28S ribosomal RNA cleavage in response to endoplasmic reticulum (ER) stress. This pro-apoptotic appears to play no role in the unfolded-protein response, unlike closely related proteins. Overexpression of ERN2 activates both BiP and CHOP expression, and also leads to the development of programmed cell death. It has been suggested that Ern2 plays a role in multiple facets of the ER stress response in mammalian cells. |
| Uniprot ID | Q76MJ5 |
| Protein Accession # | NP_150296.3 |
| Molecular Weight | 102 kDa |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "ERN2 Antibody - C-terminal region (OAAB16895)"?
The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".
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How long will it take to receive "ERN2 Antibody - C-terminal region (OAAB16895)"?
This item is available "Domestic: within 1-2 weeks delivery | International: 1-2 weeks ".
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What buffer format is "ERN2 Antibody - C-terminal region (OAAB16895)" provided in?
This item is provided in "Liquid PBS with 0.09% (W/V) sodium azide. ".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "ERN2 Antibody - C-terminal region (OAAB16895)"?
This target may also be called "IRE1b, IRE2p, hIRE2p, IRE1-BETA" in publications.
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What is the shipping cost for "ERN2 Antibody - C-terminal region (OAAB16895)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "ERN2 Antibody - C-terminal region (OAAB16895)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "ERN2 Antibody - C-terminal region (OAAB16895)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "102 kDa".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "ERN2 Antibody - C-terminal region (OAAB16895)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "ERN2"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "ERN2"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "ERN2"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "ERN2"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "ERN2"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "ERN2"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.
