ERLIN2 Recombinant Protein (OPCD00700)

Catalog No: OPCD00700

ERLIN2 Recombinant Protein (OPCD00700) using SDS-PAGE

ERLIN2 Recombinant Protein (OPCD00700) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Isoelectric Point: 5.3
  Residues: Pro47-Asn339
  Subcellular Location: Endoplasmic reticulum, Membrane
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 90%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: ERLIN2
• Gene Full Name: ER lipid raft associated 2
• Alias Symbols: C8orf2;endoplasmic reticulum lipid raft-associated protein 2;epididymis secretory sperm binding protein;erlin-2;NET32;spastic paraplegia 18 (autosomal dominant);SPFH domain family, member 2;SPFH2;SPG18;stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2.
• NCBI Gene Id: 11160
• Protein Name: Erlin-2
• Description of Target: Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1 (PubMed:19240031, PubMed:17502376). Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex (PubMed:21343306). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex (PubMed:24217618).
• Uniprot ID: O94905
• Protein Accession #: NP_001003790.1
• Nucleotide Accession #: NM_001003790.3
• Protein Size (# AA): Pro47~Asn339
• Molecular Weight: 37kDa